Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 1026 to 1050 of 1147 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


919	increased	respiratory electron transport chain (GO:0022904)	superoxide (CHEBI:18421)	2120: Superoxide generation, increased
1075	increased	serotonin receptor activity (GO:0099589)	Surface of brain (FMA:86594)	2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
984	disrupted		synapse (GO:0045202)	2005: Altered neurotransmission in development
62	decreased	synapse assembly (GO:0007416)	synapse (GO:0045202)	385: Decrease of synaptogenesis
708	abnormal	chemical synaptic transmission (GO:0007268)	synapse (GO:0045202)	758: Hippocampal Physiology, Altered
203	increased	T cell activation (GO:0042110)	T cell (CL:0000084)	272: Activation/Proliferation, T-cells
903	decreased	T cell activation involved in immune response (GO:0002286)	T cell (CL:0000084)	1702: Suppression of T cell activation
1041	increased	T cell activation involved in immune response (GO:0002286)	T cell (CL:0000084)	None
1042	increased	T cell migration (GO:0072678)	T cell (CL:0000084)	None
1054	occurrence	T cell migration (GO:0072678)	T cell (CL:0000084)	2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization
1057	occurrence	T cell activation involved in immune response (GO:0002286)	T cell (CL:0000084)	2260: Gluten-reactive CD4+ T cells, activation
728	increased	gene expression (GO:0010467)	teratocarcinoma-derived growth factor 1 (PR:000030513)	None
963	increased	Abnormality of the testis (HP:0000035)	Testis (FMA:7210)	2206: Increased, histomorphological alteration of testis
704	decreased	testicular atrophy (MP:0003205)	Testis (FMA:7210)	None
723	increased	Testicular atrophy (HP:0000029)	Testis (FMA:7210)	1506: Testicular atrophy
1028	increased	testosterone biosynthetic process (GO:0061370)	testosterone (CHEBI:17347)	2272: Testosterone levels, increased
93	decreased	testosterone biosynthetic process (GO:0061370)	testosterone (CHEBI:17347)	5 Events 413: Reduction, Testosterone synthesis in Leydig cells 274: Reduction, Testosterone synthesis by ovarian theca cells 645: Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells 1690: Decrease, circulating testosterone levels 2298: Decrease, intratesticular testosterone levels
94	decreased		testosterone (CHEBI:17347)	2 Events 446: Reduction, fetal/adult testosterone 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
265	decreased	hormone biosynthetic process (GO:0042446)	testosterone (CHEBI:17347)	2 Events 495: Repressed expression of steroidogenic enzymes 1690: Decrease, circulating testosterone levels
389	decreased	receptor binding (GO:0005102)	testosterone (CHEBI:17347)	743: Decreased, Testosterone binding to androgen receptor (hypothalamus)
40	increased	excretion (GO:0007588)	Tetrahydroaldosterone-3-glucuronide (CHEBI:88728)	401: Increase, Biliary excretion TH glucuronide
673	increased	signaling (GO:0023052)	TGF-beta (PR:000000046)	1283: Activation, TGF-beta pathway
193	increased	transforming growth factor beta1 production (GO:0032905)	TGF-beta 1 (PR:000000182)	276: Up Regulation, TGFbeta1 expression
157	increased	metabolic process (GO:0008152)	thiamethoxam (CHEBI:39185)	77: Production, Critical Metabolites (CGA 330050 and CGA 265307)
385	increased	cell proliferation (GO:0008283)	thyroid follicular cell (CL:0002258)	2 Events 739: Increase, Hypertrophy and proliferation (follicular cell) 1024: Increased, Hypertrophy and proliferation (follicular cell)