Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 1051 to 1075 of 1150 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


63	decreased	synaptic signaling (GO:0099536)		2 Events 386: Decrease of neuronal network function 618: Decreased, Neuronal network function in adult brain
94	decreased		testosterone (CHEBI:17347)	2 Events 446: Reduction, fetal/adult testosterone 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
96	decreased	androgen receptor activity (GO:0004882)	androgen receptor (PR:000004191)	2 Events 26: Antagonism, Androgen receptor 1614: Decrease, androgen receptor activation
109	decreased	egg quantity (VT:1000294)		2 Events 78: Reduction, Cumulative fecundity and spawning 972: Decreased fertility, Reduced number of oocytes ovulated
114	decreased		Luteinizing hormone (CHEBI:81568)	2 Events 129: Reduction, Gonadotropins, circulating concentrations 690: Reduced, Luteinizing hormone (LH), plasma
129	occurrence		cholestasis (MESH:D002779)	2 Events 357: Cholestasis, Pathology 1059: Increased, cholestasis
130	decreased	prostaglandin-endoperoxide synthase activity (GO:0004666)	prostaglandin G/H synthase 1 (PR:000013427)	2 Events 79: Inhibition, Cyclooxygenase activity 1103: Inhibition, Cyclooxygenase 1 activity
132	decreased		prostaglandin E2 (CHEBI:15551)	2 Events 243: Reduction, Prostaglandin E2 concentration 687: Reduced, Prostaglandin E2 concentration, hypothalamus
138	increased		vitellogenins (MESH:D014819)	2 Events 220: Increase, Plasma vitellogenin concentrations 419: Increased, renal vitellogenin deposition
139	increased	gene expression (GO:0010467)	vitellogenins (MESH:D014819)	2 Events 307: Increase, Vitellogenin synthesis in liver 418: Increased, Vitellogenin synthesis
142	abnormal	larval development (GO:0002164)		2 Events 339: Altered, Larval development 566: impaired, Larval development
144	decreased	estrogen receptor activity (GO:0030284)	estrogen receptor (PR:000007204)	2 Events 112: Antagonism, Estrogen receptor 1046: Suppression, Estrogen receptor (ER) activity
151	increased		erythrocyte (CL:0000232)	2 Events 246: Increase, RBC congestion in liver 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
167	increased	signaling (GO:0023052)	oxysterols receptor LXR-alpha (PR:000011395)	2 Events 167: Activation, LXR 483: Activation, LXR alpha
174	increased	gene expression (GO:0010467)	acyl-CoA desaturase (PR:000014497)	2 Events 258: Activation, SCD-1 462: Up Regulation, SCD-1
175	increased	fatty acid biosynthetic process (GO:0006633)	fatty acid (CHEBI:35366)	2 Events 89: Synthesis, De Novo Fatty Acid (FA) 458: Increased, De Novo FA synthesis
183	decreased	peroxisome proliferator activated receptor signaling pathway (GO:0035357)	peroxisome proliferator-activated receptor gamma (PR:000013058)	2 Events 233: Decreased, PPAR-gamma activation 1028: Activation of specific nuclear receptors, PPAR-gamma activation
186	decreased	3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857)	3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774)	2 Events 8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity 1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene
192	occurrence	liver fibrosis (MP:0003333)	liver (UBERON:0002107)	2 Events 344: Increase, Liver fibrosis 840: Formation, Liver fibrosis
207	decreased	apoptotic process (GO:0006915)		2 Events 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis 1183: Decreased, Apoptosis (Epithelial Cells)
227	increased	hepatocyte proliferation (GO:0072574)	hepatocyte (CL:0000182)	2 Events 491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) 716: Increase, cell proliferation (hepatocytes)
233	increased	hemorrhage (MP:0001914)		2 Events 421: Increased, glomerular rupture and renal hemorrhaging 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
236	decreased	iodide transport (GO:0015705)	iodide (CHEBI:16382)	2 Events 425: Decrease of Thyroidal iodide 737: Decreased, Uptake of inorganic iodide
253	increased	biosynthetic process (GO:0009058)	triglyceride (CHEBI:17855)	2 Events 454: Increased, Triglyceride formation 881: Increased, Triglyceride
265	decreased	hormone biosynthetic process (GO:0042446)	testosterone (CHEBI:17347)	2 Events 495: Repressed expression of steroidogenic enzymes 1690: Decrease, circulating testosterone levels