Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1076 to 1100 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
850 increased protease binding (GO:0002020) transmembrane protease serine 2 (human) (PR:O15393) None
503 increased binding (GO:0005488) transthyretin (PR:000016801) 957: Binding, Transthyretin in serum
618 increased reflex (GO:0060004) trigeminal nerve (UBERON:0001645) 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
246 increased triglyceride biosynthetic process (GO:0019432) triglyceride (CHEBI:17855) 454: Increased, Triglyceride formation
253 increased biosynthetic process (GO:0009058) triglyceride (CHEBI:17855)
176 increased triglyceride (CHEBI:17855) 291: Accumulation, Triglyceride
372 increased tubulin binding (GO:0015631) tubulin (PR:000028799) 718: Binding, Tubulin
722 disrupted tubulin complex (GO:0045298) 718: Binding, Tubulin
623 increased cytokine production (GO:0001816) tumor necrosis factor alpha (PR:000000134) 1224: Non-neuronal production of TNF, Epithelial irritation
828 increased Increased inflammatory response (HP:0012649) tumor necrosis factor alpha (PR:000000134) None
833 increased tumor necrosis factor secretion (GO:1990774) tumor necrosis factor alpha (PR:000000134) 1868: Hyperinflammation
788 decreased cellular response to type I interferon (GO:0071357) type I interferon receptor complex (GO:0038197) None
526 decreased catalytic activity (GO:0003824) type I iodothyronine deiodinase (PR:000006480) 1009: Inhibition, Deiodinase 1
521 decreased catalytic activity (GO:0003824) type II iodothyronine deiodinase (PR:000006481) 1002: Inhibition, Deiodinase 2
604 decreased catalytic activity (GO:0003824) type III iodothyronine deiodinase (PR:000006482) 1153: Inhibition, Deiodinase 3
405 increased tyrosine (CHEBI:18186) 775: Increased, Plasma tyrosine
778 decreased protein tyrosine kinase activity (GO:0004713) tyrosine-protein kinase fyna (zebrafish) (PR:Q6EWH2) 1884: Inhibition of Fyna
747 decreased regulation of binding (GO:0051098) tyrosine-protein kinase JAK3 (PR:000009198) 1715: Inhibition of JAK3
529 increased gene expression (GO:0010467) UDP-glucuronosyltransferase (PR:000024849) 1020: Increased, induction of UDPGT's in liver
1125 decreased mRNA transcription (GO:0009299) undifferentiated genital tubercle (UBERON:0005876) None
675 increased unsaturated fatty acid biosynthetic process (GO:0006636) unsaturated fatty acid (CHEBI:27208) 1285: Up Regulation, Unsaturated fatty acid
968 abnormal animal organ formation (GO:0048645) urethra (UBERON:0000057) 2213: Impaired, urethral tube closure
969 increased specification of animal organ position (GO:0010159) urethral opening (UBERON:0010418) None
972 abnormal specification of animal organ position (GO:0010159) urethral opening (UBERON:0010418) None
465 increased uric acid (CHEBI:27226)