Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1101 to 1125 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
928 occurrence receptor binding (GO:0005102)
929 occurrence receptor-mediated endocytosis (GO:0006898) clathrin-coated vesicle membrane (GO:0030665) None
930 occurrence protein localization to endosome (GO:0036010) clathrin-coated vesicle membrane (GO:0030665) 2159: Influenza A virus (IAV) cell entry
931 occurrence receptor-mediated endocytosis (GO:0006898) influenzavirus hemagglutinin (PR:000049750) 2159: Influenza A virus (IAV) cell entry
932 occurrence membrane fusion (GO:0061025) vesicle membrane (GO:0012506) 2159: Influenza A virus (IAV) cell entry
933 occurrence inhibition of host DNA replication by virus (GO:0098673) interferon regulatory factor 3 complex (GO:0097072) None
934 occurrence toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None
935 occurrence toll-like receptor 7 signaling pathway (GO:0034154) viral genome (GO:0019015) None
944 occurrence clathrin-dependent endocytosis (GO:0072583) None
945 occurrence vesicle targeting, plasma membrane to endosome (GO:0048201) None
946 occurrence pH reduction (GO:0045851) endosome (GO:0005768) None
947 occurrence membrane fusion (GO:0061025) influenzavirus hemagglutinin (PR:000049750) None
948 occurrence protein import into nucleus (GO:0006606) viral RNA-directed RNA polymerase complex (GO:0031381) 2192: Influenza A Virus production increased
949 occurrence transcription, RNA-templated (GO:0001172) segmented viral genome (GO:0019017) 2192: Influenza A Virus production increased
950 occurrence nuclear export (GO:0051168) viral genome (GO:0019015) None
951 occurrence viral mRNA export from host cell nucleus (GO:0046784) 2192: Influenza A Virus production increased
952 occurrence virus maturation (GO:0019075) 2192: Influenza A Virus production increased
953 occurrence suppression by virus of host cytokine production (GO:0046775) 2180: Immune mechanisms antagonized by viral proteins
954 occurrence virus induced gene silencing (GO:0009616) 2180: Immune mechanisms antagonized by viral proteins
955 occurrence modulation by virus of host immune response (GO:0075528) 2180: Immune mechanisms antagonized by viral proteins
956 occurrence viral budding from plasma membrane (GO:0046761) 2193: Influenza A Virus (IAV) budding
957 occurrence transmission of virus (GO:0019089) 2194: Influenza A Virus (IAV) shedding and transmission
974 occurrence epithelial to mesenchymal transition (GO:0001837) Epithelial cell (FMA:66768) 1457: Epithelial Mesenchymal Transition
990 occurrence Stress, Physiological (MESH:D013312) heart (UBERON:0000948) None
991 occurrence Cardiac arrest (HP:0001695) heart (UBERON:0000948) 1535: Heart failure