Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1126 to 1146 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1002 occurrence positive regulation of bone resorption (GO:0045780) 2090: Increase, Bone Remodeling
1003 occurrence abnormal bone remodeling (MP:0002998) 2090: Increase, Bone Remodeling
1007 occurrence decreased trabecular bone volume (MP:0010879) 2091: Occurrence, Bone Loss
1008 occurrence decreased bone mineral density (MP:0000063) 2091: Occurrence, Bone Loss
1051 occurrence antigen presentation trait (VT:0001835) Human leukocyte antigen complex (FMA:84795) 2252: Human leukocyte antigen DQ2/8-gluten complexes, formation
1052 occurrence gene conversion (GO:0035822) alpha-beta T cell receptor complex (GO:0042105) 2253: Gluten-reactive T cell receptors, generation
1053 occurrence gene conversion of immunoglobulin genes (GO:0002206) B cell receptor complex (GO:0019815) 2254: Gluten-reactive and transglutaminase 2 reactive B cell receptors, generation
1054 occurrence T cell migration (GO:0072678) T cell (CL:0000084) 2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization
1055 occurrence dendritic cell migration (GO:0036336) professional antigen presenting cell (CL:0000145) 2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization
1056 occurrence immune system process (GO:0002376) 2255: Innate immune response, activation
1057 occurrence T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 2260: Gluten-reactive CD4+ T cells, activation
1058 occurrence B cell activation involved in immune response (GO:0002312) B cell (CL:0000236) 2256: Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation
1068 occurrence cell activation involved in immune response (GO:0002263) None
1074 occurrence cornification (GO:0070268) epithelium of vagina (UBERON:0001344) 2306: Persistent vaginal cornification
8 pathological brain inflammation (MP:0001847) microglial cell (CL:0000129) 188: Neuroinflammation
9 pathological brain inflammation (MP:0001847) astrocyte (CL:0000127) 188: Neuroinflammation
644 pathological Breast Neoplasms (MESH:D001943) 1193: N/A, Breast Cancer
980 pathological negative regulation of synaptic plasticity (GO:0031914) postsynaptic actin cytoskeleton (GO:0098871) 2242: Abnormality, dendritic spine morphology
1050 pathological Celiac disease (HP:0002608) intestinal epithelial cell (CL:0002563) 2257: Celiac disease
309 premature aging (GO:0007568) 571: Accelerated, Aging
613 premature spawning (MESH:C82476) 1255: induced spawning