Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1126 to 1146 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
948 occurrence protein import into nucleus (GO:0006606) viral RNA-directed RNA polymerase complex (GO:0031381) 2192: Influenza A Virus production increased
591 abnormal vitamin K metabolic process (GO:0042373) vitamin K (CHEBI:28384) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
593 decreased catalytic activity (GO:0003824) Vitamin K Epoxide Reductases (MESH:D064417) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
776 decreased protein secretion (GO:0009306) vitellogenins (MESH:D014819) 285: Reduction, Vitellogenin synthesis in liver
108 decreased gene expression (GO:0010467) vitellogenins (MESH:D014819) 285: Reduction, Vitellogenin synthesis in liver
110 decreased vitellogenins (MESH:D014819) 221: Reduction, Plasma vitellogenin concentrations
111 decreased receptor-mediated endocytosis (GO:0006898) vitellogenins (MESH:D014819) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
138 increased vitellogenins (MESH:D014819)
139 increased gene expression (GO:0010467) vitellogenins (MESH:D014819)
986 functional change sodium channel activity (GO:0005272) voltage-gated sodium channel complex (GO:0001518) 1977: Disruption of sodium channel gating kinetics
717 decreased hypoxia (MP:0005039) von Hippel-Lindau disease tumor suppressor (PR:000017294) 1394: Induction, persistent proliferation/sustained proliferation
718 decreased hypoxia-inducible factor-1alpha signaling pathway (GO:0097411) von Hippel-Lindau disease tumor suppressor (PR:000017294) None
683 abnormal signaling (GO:0023052) Wnt signalosome (GO:1990909) 1294: Inhibition, Wnt pathway
97 abnormal Wnt signaling pathway (GO:0016055) Wnt signalosome (GO:1990909) 310: Alteration, Wnt pathway
148 increased hemoglobin biosynthetic process (GO:0042541) xenobiotic (CHEBI:35703) 118: Formation, Formation of hemoglobin adducts
194 increased covalent binding (MI:0195) xenobiotic (CHEBI:35703) 75: N/A, Covalent binding to protein, possibly lysine residue
885 decreased protein import into nucleus, translocation (GO:0000060) zinc finger protein GLI1 (PR:000008026) 2028: Decrease, GLI1/2 translocation to nucleus
889 decreased gene expression (GO:0010467) zinc finger protein GLI1 (PR:000008026) 2040: Decrease, GLI1/2 target gene expression
884 decreased protein import into nucleus, translocation (GO:0000060) zinc finger protein GLI1 (human) (PR:P08151) None
886 decreased protein import into nucleus, translocation (GO:0000060) zinc finger protein GLI2 (PR:000008027) 2028: Decrease, GLI1/2 translocation to nucleus
890 decreased gene expression (GO:0010467) zinc finger protein GLI2 (PR:000008027) 2040: Decrease, GLI1/2 target gene expression