Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 101 to 125 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
306 decreased reproductive behavior (GO:0019098) 565: Reduced, Brood care
244 decreased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 456: Suppression, Constitutive androstane receptor, NR1I3
238 decreased secretion (GO:0046903) very-low-density lipoprotein (CHEBI:39027) 450: Decrease, Very low-density lipoprotein export capacity
219 decreased angiogenesis (GO:0001525) 28: Reduction, Angiogenesis
264 decreased reproductive process (GO:0022414) 675: Reduced, Reproductive Success
262 decreased ovulation (GO:0030728) 488: Decrease, Ovulation
250 decreased signaling (GO:0023052) hepatocyte nuclear factor 3-beta (PR:000007603) 471: Inhibition, FoxA2
267 decreased sperm quantity (VT:0002673) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
282 decreased intracellular cholesterol transport (GO:0032367) cholesterol (CHEBI:16113) 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
265 decreased hormone biosynthetic process (GO:0042446) testosterone (CHEBI:17347)
249 decreased signaling (GO:0023052) hepatocyte nuclear factor 4-alpha (PR:000008654) 461: Suppression, HNF4alpha
294 decreased regulation of luteinizing hormone secretion (GO:0033684) Luteinizing hormone (CHEBI:81568) 531: Decreased, LH Surge
290 decreased dopamine beta-monooxygenase activity (GO:0004500) dopamine beta-hydroxylase (PR:000006294) 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase
315 decreased abnormal maternal nurturing (MP:0001386) 565: Reduced, Brood care
325 decreased sodium channel inhibitor activity (GO:0019871) sodium channel protein type 1 subunit alpha (PR:000002095)
320 decreased feeding behavior (NBO:0000079)
311 decreased population of organisms (PCO:0000001) 572: Decrease, Number of worker bees
284 decreased regulation of steroid biosynthetic process (GO:0050810) 647: Decreased, steroidogenic protein expression
339 decreased fear/anxiety related behavior (NBO:0000018) 627: Decreased, anxiety
336 decreased neurotransmitter reuptake (GO:0098810) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
327 decreased aquatic locomotion (NBO:0000371)
341 decreased serotonin uptake (GO:0051610) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
340 decreased abnormal sheltering behavior (MP:0014039) 629: Decreased, sheltering
326 decreased action potential (GO:0001508) 585: Decreased, Sodium conductance 1
283 decreased steroid biosynthetic process (GO:0006694) 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell