Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 101 to 125 of 1146 KECs

ID	Action	Process	Associated Key Events (KEs)


335	increased	fossorial locomotion behavior (NBO:0000071)	624: Increased, foot detachment
339	decreased	fear/anxiety related behavior (NBO:0000018)	627: Decreased, anxiety
333	increased	membrane depolarization (GO:0051899)	599: prolonged, Depolarization of neuronal membrane
303	increased	colony collapse (MESH:D056631)	2 Events 563: Death/Failure, Colony 1107: Weakened, Colony
105	morphological change	abnormal cardiovascular system physiology (MP:0001544)	317: Altered, Cardiovascular development/function
201	increased	cell activation (GO:0001775)	3 Events 398: Activation, Dendritic Cells 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 981: Reduction, NFAT/AP-1 complex formation
391	increased	neoplasm (MP:0002006)	745: Increase, Leydig cell tumors
200	increased	cytokine production involved in inflammatory response (GO:0002534)	826: Activation, Keratinocytes
109	decreased	egg quantity (VT:1000294)	2 Events 78: Reduction, Cumulative fecundity and spawning 972: Decreased fertility, Reduced number of oocytes ovulated
1146	increased	Hepatic bridging fibrosis (HP:0012852)	2414: COL3A1 Signaling Pathway
128	increased	inflammatory response (GO:0006954)	5 Events 149: Increase, Inflammation 901: Infiltration, Inflammatory cells 1087: Increased, inflammation 1225: Immune system inflammation 2097: Increase, Pro-Inflammatory Mediators
112	decreased	oocyte growth (GO:0001555)	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
113	decreased	oocyte development (GO:0048599)	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
223	morphological change	anatomical structure morphogenesis (GO:0009653)	1001: Increased, Developmental Defects
220	abnormal	endothelium development (GO:0003158)	110: Impairment, Endothelial network
309	premature	aging (GO:0007568)	571: Accelerated, Aging
314	increased	Appetite (MESH:D001066)	574: Increased, Appetite and hunger
225	increased	metabolic process (GO:0008152)	409: Metabolism of AFB1, Production of Reactive Electrophiles
330	decreased	hypoxia (MP:0005039)	590: N/A, hypoxia
142	abnormal	larval development (GO:0002164)	2 Events 339: Altered, Larval development 566: impaired, Larval development
161	increased	hepatotoxicity (MI:2141)	270: Induction, Sustained Hepatotoxicity
122	decreased	long-term synaptic potentiation (GO:0060291)	166: Decreased, Long-term potentiation (LTP)
123	increased	oxidative stress (MP:0003674)	3 Events 209: Peptide Oxidation 1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK 1392: Increase, Oxidative Stress
320	decreased	feeding behavior (NBO:0000079)	3 Events 561: Reduced, Food storage 587: Reduced, feeding 1 1016: Inhibition, Feeding
326	decreased	action potential (GO:0001508)	585: Decreased, Sodium conductance 1