Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 101 to 125 of 1146 KECs

ID	Action	Object	Associated Key Events (KEs)


558	increased	adenosquamous carcinoma (MESH:D018196)	1070: Increased, adenosquamous carcinomas of endometrium
151	increased	erythrocyte (CL:0000232)	2 Events 246: Increase, RBC congestion in liver 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
366	increased	Adenoma (MESH:D000236)	9 Events 713: Increase, Adenomas/carcinomas (renal tubular) 719: Increase, hepatocellular adenomas and carcinomas 736: Increase, Adenomas/carcinomas (bronchioloalveolar) 741: Increase, Adenomas/carcinomas (follicular cell) 773: Increase, Endometrial adenocarcinomas 797: Increase, Adenomas/carcinomas (urothelial) 1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell) 1053: Promotion, ovarian adenomas 1079: Increased, Adenomas/carcinomas (mammary)
774	increased	deoxyribonucleic acid (CHEBI:16991)	1879: Bulky DNA adducts, increase
277	decreased	sperm (CL:0000019)	4 Events 505: Decreased sperm quantity / quality in the adult, Decreased fertility 646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis 520: Decreased sperm quantity or quality in the adult, Decreased fertility 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
621	increased	Dyspnea (MESH:D004417)	1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
398	decreased	population quality (PCO:0000003)	765: Decreased, population 1
645	functional change	deoxyribonucleic acid (CHEBI:16991)	1194: Increase, DNA damage
110	decreased	vitellogenins (MESH:D014819)	221: Reduction, Plasma vitellogenin concentrations
679	abnormal	cholesterol (CHEBI:16113)	1289: Perturbation of cholesterol
452	increased	porphyrins (CHEBI:26214)	846: Accumulation, Highly carboxylated porphyrins
271	increased	corticosterone (CHEBI:16827)	653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone
114	decreased	Luteinizing hormone (CHEBI:81568)	2 Events 129: Reduction, Gonadotropins, circulating concentrations 690: Reduced, Luteinizing hormone (LH), plasma
115	decreased	Follicle stimulating hormone (CHEBI:81569)	129: Reduction, Gonadotropins, circulating concentrations
467	increased	potassium atom (CHEBI:26216)	1098: Increased, blood potassium concentration
117	increased	calcium ion (CHEBI:39124)	50: Increase, Ca++ (intracellular)
118	disrupted	mitochondrial respiratory chain (GO:0005746)	178: Mitochondrial electron transport chain, disrupted
548	increased	Granular Cell Tumor (MESH:D016586)	1054: Promotion, ovarian granular cell tumors
658	increased	male organism (UBERON:0003101)	1208: Increased, Male offspring
121	decreased	nitric oxide (CHEBI:16480)	193: Decreased, Nitric Oxide
462	increased	Metaplasia (MESH:D008679)	869: Increase, Respiratory or Squamous Metaplasia
222	abnormal	capillary plexus (UBERON:0035753)	298: Insufficiency, Vascular
129	occurrence	cholestasis (MESH:D002779)	2 Events 357: Cholestasis, Pathology 1059: Increased, cholestasis
575	increased	3,3',5-triiodo-L-thyronine (CHEBI:18258)	1116: Decreased, Triiodothyronine (T3) in tissues
126	increased	bile (UBERON:0001970)	214: Bile accumulation, Pathological condition