Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 126 to 150 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
881 decreased receptor antagonist activity (GO:0048019) smoothened homolog (human) (PR:Q99835) None
713 decreased abnormal circulating hormone level (MP:0005418) None
721 increased DNA molecule region (FMA:84119) None
560 delayed estrus (GO:0060209) None
177 functional change mitochondrion disassembly (GO:0061726) mitochondrion (GO:0005739) None
579 increased reactive oxygen species (CHEBI:26523) None
696 decreased vascular endothelial growth factor A (PR:000017284) None
691 increased acute inflammatory response (GO:0002526) Cytokine (FMA:84050) None
704 decreased testicular atrophy (MP:0003205) Testis (FMA:7210) None
523 decreased survival (MESH:D013534) None
775 decreased protein secretion (GO:0009306) None
474 decreased epithelial cell apoptotic process (GO:1904019) None
726 decreased androgen biosynthetic process (GO:0006702) None
743 decreased regulation of binding (GO:0051098) None
744 decreased protein dephosphorylation (GO:0006470) None
730 decreased activin receptor signaling pathway (GO:0032924) activin receptor complex (GO:0048179) None
187 increased fatty liver (MESH:D005234) None
767 increased endocytosis involved in viral entry into host cell (GO:0075509) None
772 occurrence epithelial to mesenchymal transition (GO:0001837) cellular_component (GO:0005575) None
769 increased neuropilin binding (GO:0038191) None
786 decreased pattern recognition receptor signaling pathway (GO:0002221) RNA viral genome (GO:0019022) None
790 decreased translation (GO:0006412) None
788 decreased cellular response to type I interferon (GO:0071357) type I interferon receptor complex (GO:0038197) None
429 decreased cholesterol (CHEBI:16113) None
1146 increased Hepatic bridging fibrosis (HP:0012852) 2414: COL3A1 Signaling Pathway