Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 151 to 175 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
753 decreased growth (GO:0040007) multicellular organism (UBERON:0000468) 1521: Decrease, Growth
775 decreased protein secretion (GO:0009306) None
776 decreased protein secretion (GO:0009306) vitellogenins (MESH:D014819) 285: Reduction, Vitellogenin synthesis in liver
777 decreased mRNA transcription (GO:0009299) aromatase (PR:000006100) 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
778 decreased protein tyrosine kinase activity (GO:0004713) tyrosine-protein kinase fyna (zebrafish) (PR:Q6EWH2) 1884: Inhibition of Fyna
779 decreased microphthalmia (MP:0001297) eye (UBERON:0000970) 1878: Decreased, Eye size
781 decreased negative regulation of blood coagulation (GO:0030195) 1866: Fibrinolysis, decreased
786 decreased pattern recognition receptor signaling pathway (GO:0002221) RNA viral genome (GO:0019022) None
787 decreased type I interferon signaling pathway (GO:0060337) signalling molecule (CHEBI:62488) None
788 decreased cellular response to type I interferon (GO:0071357) type I interferon receptor complex (GO:0038197) None
789 decreased transcription, DNA-templated (GO:0006351) None
790 decreased translation (GO:0006412) None
791 decreased chloride channel activity (GO:0005254) 1906: Cystic Fibrosis Transmembrane Regulator Function, Decreased
792 decreased epithelial cilium movement (GO:0003351) None
793 decreased regulation of cilium movement (GO:0003352) None
794 decreased mucociliary clearance trait (VT:0001947) 1909: Mucociliary Clearance, Decreased
795 decreased mitochondrion (GO:0005739) None
796 decreased ATP synthesis coupled proton transport (GO:0015986) mitochondrion (GO:0005739) None
798 decreased regulation of mitochondrial membrane potential (GO:0051881) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
800 decreased epithelial lining fluid (UBERON:0035963) 1907: Airway Surface Liquid Height, Decreased
801 decreased Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) None
807 decreased motile cilium (GO:0031514) 1912: Motile Cilia Number/Length, Decreased
808 decreased forkhead box protein J1 (PR:000007628) 1911: FOXJ1 Protein, Decreased
809 decreased cftr isoform 1 (PR:000001045) None
814 decreased angiotensin-converting enzyme 2 (PR:000003622) None