Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 151 to 175 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
14 increased chitin biosynthetic process (GO:0006031) chitin (CHEBI:17029) 990: Increase, Incomplete ecdysis
222 abnormal capillary plexus (UBERON:0035753) 298: Insufficiency, Vascular
182 decreased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor delta (PR:000013057) 232: Decreased, PPAR-beta activation
28 abnormal abnormal lipid homeostasis (MP:0002118) 862: Not Increased, Circulating Ketone Bodies
29 abnormal ketone body (CHEBI:73693) 862: Not Increased, Circulating Ketone Bodies
30 increased protein catabolic process (GO:0030163) muscle protein (MESH:D009124) 863: Increased, Catabolism of Muscle Protein
1146 increased Hepatic bridging fibrosis (HP:0012852) 2414: COL3A1 Signaling Pathway
56 decreased secretion (GO:0046903) brain-derived neurotrophic factor (PR:000004716) 381: Reduced levels of BDNF
58 increased neurodegeneration (MP:0002229) 352: N/A, Neurodegeneration
59 decreased learning (GO:0007612) 341: Impairment, Learning and memory
60 abnormal dendrite morphogenesis (GO:0048813) dendrite (GO:0030425) 382: Aberrant, Dendritic morphology
62 decreased synapse assembly (GO:0007416) synapse (GO:0045202) 385: Decrease of synaptogenesis
112 decreased oocyte growth (GO:0001555) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
113 decreased oocyte development (GO:0048599) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
224 abnormal DNA alkylation (GO:0006305) Nuclear deoxyribonucleic acid (FMA:67194) 373: Formation, Pro-mutagenic DNA Adducts
115 decreased Follicle stimulating hormone (CHEBI:81569) 129: Reduction, Gonadotropins, circulating concentrations
116 decreased calcium-transporting ATPase activity (GO:0005388) calcium ion-transporting ATPase complex (GO:0090534) 51: Inhibition, Ca++ ATPase
117 increased calcium ion (CHEBI:39124) 50: Increase, Ca++ (intracellular)
118 disrupted mitochondrial respiratory chain (GO:0005746) 178: Mitochondrial electron transport chain, disrupted
120 increased reactive oxygen species biosynthetic process (GO:1903409) reactive oxygen species (CHEBI:26523) 1115: Increase, Reactive oxygen species
121 decreased nitric oxide (CHEBI:16480) 193: Decreased, Nitric Oxide
122 decreased long-term synaptic potentiation (GO:0060291) 166: Decreased, Long-term potentiation (LTP)
124 decreased transport (GO:0006810) bile salt export pump (PR:000003549) 41: Inhibition, Bile Salt Export Pump (ABCB11)
125 increased gene expression (GO:0010467) bile acid receptor (PR:000011396) 288: Activation of specific nuclear receptors, Transcriptional change
126 increased bile (UBERON:0001970) 214: Bile accumulation, Pathological condition