Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 151 to 175 of 1146 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


465	increased		uric acid (CHEBI:27226)	2 Events 1096: Increased, blood uric acid concentration 1102: Occurrence, tophi (urate) deposition
467	increased		potassium atom (CHEBI:26216)	1098: Increased, blood potassium concentration
468	increased		Arrhythmias, Cardiac (MESH:D001145)	1106: Occurrence, cardiac arrhythmia
469	increased		Neoplasms (MESH:D009369)	885: Increase, Cancer
186	decreased	3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857)	3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774)	2 Events 8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity 1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene
406	decreased	4-hydroxyphenylpyruvate dioxygenase activity (GO:0003868)	4-hydroxyphenylpyruvate dioxygenase (rat) (PR:P32755)	766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
624	increased	abnormal acute inflammation (MP:0002498)		1225: Immune system inflammation
276	increased	abnormal adult Leydig cell differentiation (MP:0013604)		541: Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
441	increased	abnormal amino acid level (MP:0005332)		813: Increased, Serum creatinine
912	occurrence	abnormal blood coagulation (MP:0002551)	blood (UBERON:0000178)	1845: Coagulation
1003	occurrence	abnormal bone remodeling (MP:0002998)		2090: Increase, Bone Remodeling
105	morphological change	abnormal cardiovascular system physiology (MP:0001544)		317: Altered, Cardiovascular development/function
299	increased	abnormal chromosome number (MP:0004023)		3 Events 536: Altered, Chromosome number (polyploid) zygote 723: Altered, Chromosome number 728: Increase, Aneuploid offspring
801	decreased	Abnormal ciliary motility (HP:0012262)	motile cilium (GO:0031514)	None
802	occurrence	Abnormal ciliary motility (HP:0012262)	motile cilium (GO:0031514)	1908: Cilia Beat Frequency, Decreased
711	decreased	abnormal circulating hormone level (MP:0005418)	3,3',5'-triiodothyronine (CHEBI:28774)	None
712	decreased	abnormal circulating hormone level (MP:0005418)	3,3',5-triiodo-L-thyronine (CHEBI:18258)	None
713	decreased	abnormal circulating hormone level (MP:0005418)		None
710	decreased	abnormal circulating thyroxine level (MP:0005475)	thyroxine (CHEBI:30660)	281: Thyroxine (T4) in serum, Decreased
864	increased	abnormal DNA repair (MP:0008058)	DNA repair complex (GO:1990391)	1669: Increased, DNA damage and mutation
981	morphological change	abnormal excitatory postsynaptic current amplitude (MP:0011267)	dendritic spine membrane (GO:0032591)	388: Overactivation, NMDARs
273	increased	abnormal fetal Leydig cell differentiation (MP:0013603)		3 Events 657: Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells 660: decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells 540: Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells
911	decreased	abnormal glutathione level (MP:0012603)	glutathione (CHEBI:16856)	130: Depletion, GSH
28	abnormal	abnormal lipid homeostasis (MP:0002118)		862: Not Increased, Circulating Ketone Bodies
1071	disrupted	abnormal lipid metabolism (MP:0013245)		2300: Disruption, Glucolipid metabolism