Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 176 to 200 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
817 decreased protein localization to cell surface (GO:0034394) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
820 decreased apoptotic process (GO:0006915) ciliated epithelial cell (CL:0000067) 914: Decrease, Apoptosis of ciliated epithelial cells
838 decreased Lymphopenia (HP:0001888) lymphocyte (CL:0000542) 1868: Hyperinflammation
878 decreased type I interferon signaling pathway (GO:0060337) interferon alpha (PR:000024938) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
879 decreased type I interferon signaling pathway (GO:0060337) interferon beta (PR:000024939) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
881 decreased receptor antagonist activity (GO:0048019) smoothened homolog (human) (PR:Q99835) None
882 decreased smoothened (PR:000015288) None
883 decreased regulation of receptor activity (GO:0010469) smoothened (PR:000015288) 2027: Antagonism, Smoothened receptor
884 decreased protein import into nucleus, translocation (GO:0000060) zinc finger protein GLI1 (human) (PR:P08151) None
885 decreased protein import into nucleus, translocation (GO:0000060) zinc finger protein GLI1 (PR:000008026) 2028: Decrease, GLI1/2 translocation to nucleus
886 decreased protein import into nucleus, translocation (GO:0000060) zinc finger protein GLI2 (PR:000008027) 2028: Decrease, GLI1/2 translocation to nucleus
888 decreased gene expression (GO:0010467)
889 decreased gene expression (GO:0010467) zinc finger protein GLI1 (PR:000008026) 2040: Decrease, GLI1/2 target gene expression
890 decreased gene expression (GO:0010467) zinc finger protein GLI2 (PR:000008027) 2040: Decrease, GLI1/2 target gene expression
891 decreased secondary palatal shelf (UBERON:0005619) None
892 decreased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) None
893 decreased abnormal palatal shelf fusion at midline (MP:0009887) secondary palate (UBERON:0001716) None
896 decreased second-messenger-mediated signaling (GO:0019932) None
897 decreased protein localization to cilium (GO:0061512) smoothened (PR:000015288) 2044: Decrease, Smoothend relocation and activation
898 decreased decreased triiodothyronine level (MP:0005473) 3,3',5'-triiodothyronine (CHEBI:28774) 1003: Decreased, Triiodothyronine (T3)
903 decreased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 1702: Suppression of T cell activation
906 decreased sonic hedgehog protein (PR:000014841) None
907 decreased second-messenger-mediated signaling (GO:0019932) sonic hedgehog protein (PR:000014841) 2043: Decrease, Sonic Hedgehog second messenger production
911 decreased abnormal glutathione level (MP:0012603) glutathione (CHEBI:16856) 130: Depletion, GSH
913 decreased fibrinolysis (GO:0042730) Fibrin (CHEBI:5054) None