Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 201 to 225 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
941 increased acute-phase response (GO:0006953) None
943 increased acute-phase response (GO:0006953) Acute phase proteins (N/A)
309 premature aging (GO:0007568) 571: Accelerated, Aging
269 abnormal anatomical structure development (GO:0048856) nervous system (UBERON:0001016) 186: Altered, Neuroanatomy
223 morphological change anatomical structure morphogenesis (GO:0009653) 1001: Increased, Developmental Defects
726 decreased androgen biosynthetic process (GO:0006702) None
727 decreased androgen biosynthetic process (GO:0006702) 11-Keto-testosterone (CHEBI:34133) 1756: Decreased, plasma 11-ketotestosterone level
1033 increased androgen biosynthetic process (GO:0006702) 17beta-hydroxy-5alpha-androstan-3-one (CHEBI:16330) 2273: Dihydrotestosterone (DHT) levels, increased
96 decreased androgen receptor activity (GO:0004882) androgen receptor (PR:000004191)
107 increased androgen receptor activity (GO:0004882) androgen receptor (PR:000004191) 25: Agonism, Androgen receptor
1092 arrested androgen receptor signaling pathway (GO:0030521) androgen receptor (PR:000004191) None
1093 decreased androgen receptor signaling pathway (GO:0030521) androgen receptor (PR:000004191) None
732 disrupted androgen receptor signaling pathway (GO:0030521) Musculature of male perineum (FMA:264621) 1688: anogenital distance (AGD), decreased
588 occurrence anemia (MP:0001577) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
650 increased angiogenesis (GO:0001525) 1213: Increased, Angiogenesis
219 decreased angiogenesis (GO:0001525) 28: Reduction, Angiogenesis
973 abnormal animal organ development (GO:0048513) 1616: Malformation, cryptorchidism - maldescended testis
979 abnormal animal organ development (GO:0048513) gonad (UBERON:0000991) 1615: Impaired inguinoscrotal testicular descent phase
966 abnormal animal organ formation (GO:0048645) epididymis (UBERON:0001301) 2212: Epididymal agenesis
968 abnormal animal organ formation (GO:0048645) urethra (UBERON:0000057) 2213: Impaired, urethral tube closure
1034 increased antigen presentation trait (VT:0001835) Human leukocyte antigen complex (FMA:84795) None
1051 occurrence antigen presentation trait (VT:0001835) Human leukocyte antigen complex (FMA:84795) 2252: Human leukocyte antigen DQ2/8-gluten complexes, formation
629 increased antigen processing and presentation (GO:0019882) hapten (CHEBI:59174) 1236: Generation of novel epitopes , Antigen presentation
491 abnormal antioxidant activity (GO:0016209) glutathione (CHEBI:16856) 926: Oxidation, Glutathione (To be considered with MIE)
266 increased apoptotic process (GO:0006915)