Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1 to 25 of 1146 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
613 premature spawning (MESH:C82476) 1255: induced spawning
309 premature aging (GO:0007568) 571: Accelerated, Aging
8 pathological brain inflammation (MP:0001847) microglial cell (CL:0000129) 188: Neuroinflammation
9 pathological brain inflammation (MP:0001847) astrocyte (CL:0000127) 188: Neuroinflammation
980 pathological negative regulation of synaptic plasticity (GO:0031914) postsynaptic actin cytoskeleton (GO:0098871) 2242: Abnormality, dendritic spine morphology
1050 pathological Celiac disease (HP:0002608) intestinal epithelial cell (CL:0002563) 2257: Celiac disease
644 pathological Breast Neoplasms (MESH:D001943) 1193: N/A, Breast Cancer
443 occurrence autophagic cell death (GO:0048102) renal tubule (UBERON:0009773) 818: Occurrence, Cytoplasmic vacuolization (Renal tubule)
260 occurrence inflammatory response (GO:0006954) 486: systemic inflammation leading to hepatic steatosis
442 occurrence toxicity (MESH:Q000633) kidney (UBERON:0002113) 814: Occurrence, Kidney toxicity
447 occurrence Mallory bodies (MP:0014045) 839: Formation, Mallory body
84 occurrence protein binding (GO:0005515) Selenium-Binding Proteins (MESH:D051137) 261: Binding, SH-/selen-proteins
178 occurrence fatty liver (MESH:D005234) 345: N/A, Liver Steatosis
208 occurrence Liver Diseases (MESH:D008107) 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects
87 occurrence oxidative stress (MP:0003674) None
50 occurrence membrane depolarization (GO:0051899) 616: Occurrence, A paroxysmal depolarizing shift
53 occurrence seizures (NBO:0000025) 613: Occurrence, Epileptic seizure
466 occurrence renal tubular necrosis (MP:0004154) 1097: Occurrence, renal proximal tubular necrosis
445 occurrence podocyte vacuolization (MP:0011899) 824: Occurrence, Cytoplasmic vacuolization (podocyte)
156 occurrence Cyanosis (MESH:D003490) 321: N/A, Cyanosis occurs
11 occurrence Parkinsonian disorders (MESH:D020734) 896: Parkinsonian motor deficits
450 occurrence autophagic cell death (GO:0048102)
470 occurrence organelle disassembly (GO:1903008) lysosome (GO:0005764) 898: Disruption, Lysosome
52 occurrence excitatory postsynaptic potential (GO:0060079) 682: Generation, Amplified excitatory postsynaptic potential (EPSP)
129 occurrence cholestasis (MESH:D002779)