Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 1 to 25 of 1146 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


367	increased		Carcinoma (MESH:D002277)	10 Events 713: Increase, Adenomas/carcinomas (renal tubular) 719: Increase, hepatocellular adenomas and carcinomas 736: Increase, Adenomas/carcinomas (bronchioloalveolar) 741: Increase, Adenomas/carcinomas (follicular cell) 773: Increase, Endometrial adenocarcinomas 779: Increase, Papillomas/carcinomas (squamous cells) 797: Increase, Adenomas/carcinomas (urothelial) 1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell) 1063: Increased, Pancreatic acinar tumors 1079: Increased, Adenomas/carcinomas (mammary)
366	increased		Adenoma (MESH:D000236)	9 Events 713: Increase, Adenomas/carcinomas (renal tubular) 719: Increase, hepatocellular adenomas and carcinomas 736: Increase, Adenomas/carcinomas (bronchioloalveolar) 741: Increase, Adenomas/carcinomas (follicular cell) 773: Increase, Endometrial adenocarcinomas 797: Increase, Adenomas/carcinomas (urothelial) 1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell) 1053: Promotion, ovarian adenomas 1079: Increased, Adenomas/carcinomas (mammary)
100	decreased		fertility (MESH:D005298)	6 Events 337: N/A, Impairment of reproductive capacity 505: Decreased sperm quantity / quality in the adult, Decreased fertility 520: Decreased sperm quantity or quality in the adult, Decreased fertility 527: Decreased, Decreased fecundity 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis 330: Decrease, Fertility
82	increased	paralysis (MP:0000753)		5 Events 39: Increased Cholinergic Signaling 602: Increased, Ataxia, paralysis, or hyperactivity 764: N/A, Ataxia, paralysis, or hyperactivity 1014: Induction, Somatic muscle paralysis 1019: Induction, pharyngeal muscle paralysis
128	increased	inflammatory response (GO:0006954)		5 Events 149: Increase, Inflammation 901: Infiltration, Inflammatory cells 1087: Increased, inflammation 1225: Immune system inflammation 2097: Increase, Pro-Inflammatory Mediators
93	decreased	testosterone biosynthetic process (GO:0061370)	testosterone (CHEBI:17347)	5 Events 413: Reduction, Testosterone synthesis in Leydig cells 274: Reduction, Testosterone synthesis by ovarian theca cells 645: Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells 1690: Decrease, circulating testosterone levels 2298: Decrease, intratesticular testosterone levels
119	decreased	ATP biosynthetic process (GO:0006754)	ATP (CHEBI:15422)	4 Events 40: Mitochondrial ATP production, decreased 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP 1771: Decrease, Adenosine triphosphate pool 1472: Decrease, ATP production
26	decreased	fatty acid beta-oxidation (GO:0006635)	fatty acid (CHEBI:35366)	4 Events 859: Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids 860: Decreased, Mitochondrial Fatty Acid Beta Oxidation 179: Decrease, Fatty acid beta-oxidation 451: Inhibition, Mitochondrial fatty acid beta-oxidation
83	decreased	population growth rate (PCO:0000008)		4 Events 442: Decreased, Population trajectory 361: Decline, Population 679: Decline, Population trajectory 1136: Impaired recruitment , Population trajectory
16	increased	mortality (MESH:D009026)		4 Events 351: Increased Mortality 350: Increase, Mortality 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction 947: Increase, Early Life Stage Mortality
277	decreased		sperm (CL:0000019)	4 Events 505: Decreased sperm quantity / quality in the adult, Decreased fertility 646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis 520: Decreased sperm quantity or quality in the adult, Decreased fertility 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
450	occurrence	autophagic cell death (GO:0048102)		4 Events 833: Occurrence, Cytoplasmic vacuolization (hepatocyte) 835: Occurrence, Ballooning degeneration (hepatocyte) 836: Occurrence, Cytoplasmic vacuolization (Bile duct cell) 837: Occurrence, Cytoplasmic vacuolization (kupffer cell)
273	increased	abnormal fetal Leydig cell differentiation (MP:0013603)		3 Events 657: Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells 660: decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells 540: Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells
172	increased	SREBP signaling pathway (GO:0032933)	sterol regulatory element-binding protein 1 (PR:000015611)	3 Events 264: Activation, SREBP-1c 878: Inhibition, SREBP1c 457: Activation, SREBF1
65	increased	glucocorticoid receptor activity (GO:0004883)	glucocorticoid receptor (PR:000011406)	3 Events 122: Increase, Glucocorticoid receptor activation 494: Glucocorticoid Receptor Agonist, Activation 654: Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
137	increased	estrogen receptor activity (GO:0030284)	estrogen receptor (PR:000007204)	3 Events 111: Agonism, Estrogen receptor 659: Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists 748: Increased, Estrogen receptor (ER) activity
274	increased	Testicular dysgenesis (HP:0008715)		3 Events 657: Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells 660: decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells 540: Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells
81	increased	hyperactivity (MP:0001399)		3 Events 39: Increased Cholinergic Signaling 602: Increased, Ataxia, paralysis, or hyperactivity 764: N/A, Ataxia, paralysis, or hyperactivity
73	increased	mutation (MESH:D009154)	deoxyribonucleic acid (CHEBI:16991)	3 Events 185: Increase, Mutations 336: Increase, Heritable mutations in offspring 876: Increase, Mutations in Critical Genes
163	increased		hepatocellular carcinoma (MESH:D006528)	3 Events 347: Formation, Liver tumor 856: Formation, Hepatocellular and Bile duct tumors 378: Tumorigenesis, Hepatocellular carcinoma
32	decreased	aromatase activity (GO:0070330)	aromatase (PR:000006100)	3 Events 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) 36: Inhibition, Aromatase 800: Decreased, Aromatase (Cyp19a1) mRNA
266	increased	apoptotic process (GO:0006915)		3 Events 496: Increased apoptosis, decreased fetal/adult Leydig Cells 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells 1262: Apoptosis
41	decreased		thyroxine (CHEBI:30660)	3 Events 771: Decrease, Serum thyroid hormone (T4/T3) 1022: Decreased, serum T4/T3 1093: Decreased, Thyroxine (T4) in tissues
201	increased	cell activation (GO:0001775)		3 Events 398: Activation, Dendritic Cells 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 981: Reduction, NFAT/AP-1 complex formation
2	increased	hyperplasia (MESH:D006965)		3 Events 142: Hyperplasia, Hyperplasia 415: Hyperplasia, Leydig cell 1192: Increased, Ductal Hyperplasia