Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 226 to 250 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1055 occurrence dendritic cell migration (GO:0036336) professional antigen presenting cell (CL:0000145) 2275: Gluten reactive adaptive T-cells with antigen presenting cells, co-localization
1095 increased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) 2041: Decrease, facial prominence outgrowth
892 decreased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) None
1134 delayed delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
1135 arrested delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
1133 disrupted external genitalia morphogenesis (GO:0035261) prepuce (UBERON:0011374) 2400: Preputial epithelial morphogenesis, disrupted
331 decreased potassium channel inhibitor activity (GO:0019870) potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809) 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
362 decreased ion channel activity (GO:0005216) potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809) 697: impaired, ion channels
467 increased potassium atom (CHEBI:26216) 1098: Increased, blood potassium concentration
980 pathological negative regulation of synaptic plasticity (GO:0031914) postsynaptic actin cytoskeleton (GO:0098871) 2242: Abnormality, dendritic spine morphology
522 decreased swim bladder inflation (GO:0048798) posterior chamber swim bladder (UBERON:2001278) 1004: Reduced, Posterior swim bladder inflation
452 increased porphyrins (CHEBI:26214) 846: Accumulation, Highly carboxylated porphyrins
398 decreased population quality (PCO:0000003) 765: Decreased, population 1
311 decreased population of organisms (PCO:0000001) 572: Decrease, Number of worker bees
612 increased population of organisms (PCO:0000001) 1164: Increased, Population
1144 increased female sex determination (GO:0030237) population of organisms (PCO:0000001) 2418: Increased, phenotypic female-biased sex ratio
739 decreased population growth rate (PCO:0000008) population of organisms (PCO:0000001) 360: Decrease, Population growth rate
741 increased male sex differentiation (GO:0046661) population of organisms (PCO:0000001) 1791: Increased, Male Biased Sex Ratio
962 increased lipid oxidation (GO:0034440) polyunsaturated fatty acid (CHEBI:26208) 1445: Increase, Lipid peroxidation
571 increased cell death (GO:0008219) pleura (UBERON:0000977) 1086: persistent, cytotoxicity (pleura or peritoneum)
169 increased gene expression (GO:0010467) platelet glycoprotein 4 (PR:000001905) 54: Up Regulation, CD36
759 increased Venous thrombosis (HP:0004936) platelet (CL:0000233) 1846: Thrombosis and Disseminated Intravascular Coagulation
180 abnormal plasma membrane (GO:0005886) 169: Disruption, Membrane integrity
632 increased oxidation-reduction process (GO:0055114) plasma membrane (GO:0005886) 1238: Activation of oxidative stress pathway
449 decreased phospholipase activity (GO:0004620) phospholipase A1 member A (human) (PR:Q53H76) 828: Inhibition, Phospholipase A