Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 226 to 250 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
432 decreased reduced fertility (MP:0001921) fertility (MESH:D005298) 527: Decreased, Decreased fecundity
242 increased receptor-mediated endocytosis (GO:0006898) low-density lipoprotein (CHEBI:39026) 467: Increased, LDL uptake
929 occurrence receptor-mediated endocytosis (GO:0006898) clathrin-coated vesicle membrane (GO:0030665) None
931 occurrence receptor-mediated endocytosis (GO:0006898) influenzavirus hemagglutinin (PR:000049750) 2159: Influenza A virus (IAV) cell entry
111 decreased receptor-mediated endocytosis (GO:0006898) vitellogenins (MESH:D014819) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
25 decreased receptor transactivation (GO:0035624) peroxisome proliferator-activated receptor alpha (PR:000013056) 858: Decreased, PPARalpha transactivation of gene expression
272 increased receptor transactivation (GO:0035624) COUP transcription factor 2 (PR:000011405) 655: Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
275 decreased receptor transactivation (GO:0035624) COUP transcription factor 2 (PR:000011405)
323 decreased receptor regulator activity (GO:0030545) 663: Desensitization, Nicotinic acetylcholine receptor
389 decreased receptor binding (GO:0005102) testosterone (CHEBI:17347) 743: Decreased, Testosterone binding to androgen receptor (hypothalamus)
872 occurrence receptor binding (GO:0005102) angiotensin-converting enzyme 2 (PR:000003622) 1739: Binding to ACE2
928 occurrence receptor binding (GO:0005102)
881 decreased receptor antagonist activity (GO:0048019) smoothened homolog (human) (PR:Q99835) None
22 increased receptor antagonist activity (GO:0048019) peroxisome proliferator-activated receptor alpha (PR:000013056) 998: Binding of antagonist, PPAR alpha
1105 increased receptor agonist activity (GO:0048018) estrogen receptor (PR:000007204) 111: Agonism, Estrogen receptor
120 increased reactive oxygen species biosynthetic process (GO:1903409) reactive oxygen species (CHEBI:26523) 1115: Increase, Reactive oxygen species
379 increased pyruvate dehydrogenase activity (GO:0004738) pyruvate dehydrogenase [ubiquinone] (PR:000023575) 726: Increased, Induction of pyruvate dehydrogenase (PDH)
380 decreased pyruvate dehydrogenase activity (GO:0004738) Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (rat) (PR:Q63065) 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
1089 increased Pulmonary edema (HP:0100598) lung (UBERON:0002048) 2316: Increased, pulmonary edema
799 increased proton binding (GO:1901691) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
7 abnormal Proteostasis deficiencies (MESH:D057165) protein (CHEBI:36080) 889: Proteostasis, impaired
778 decreased protein tyrosine kinase activity (GO:0004713) tyrosine-protein kinase fyna (zebrafish) (PR:Q6EWH2) 1884: Inhibition of Fyna
775 decreased protein secretion (GO:0009306) None
776 decreased protein secretion (GO:0009306) vitellogenins (MESH:D014819) 285: Reduction, Vitellogenin synthesis in liver
1147 increased protein oxidation (GO:0018158) 1767: Increase, Protein oxidation