Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 301 to 325 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
266 increased apoptotic process (GO:0006915)
271 increased corticosterone (CHEBI:16827) 653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone
272 increased receptor transactivation (GO:0035624) COUP transcription factor 2 (PR:000011405) 655: Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
273 increased abnormal fetal Leydig cell differentiation (MP:0013603)
274 increased Testicular dysgenesis (HP:0008715)
276 increased abnormal adult Leydig cell differentiation (MP:0013604) 541: Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
278 increased estrogen receptor (PR:000007204) 658: Decreased testosterone by the fetal Leydig cells, Increased estradiol
285 increased apoptotic process (GO:0006915) Leydig cell (CL:0000178) 648: Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells
287 increased glucocorticoid biosynthetic process (GO:0006704) glucocorticoid (CHEBI:24261) 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
299 increased abnormal chromosome number (MP:0004023)
300 increased DNA hypermethylation (GO:0044026) 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
301 increased acetylcholine receptor activity (GO:0015464) Nicotinic acetylcholine receptor (FMA:61796) 559: Activation, Nicotinic acetylcholine receptor
303 increased colony collapse (MESH:D056631)
312 increased increased energy expenditure (MP:0004889)
313 increased Stress, Physiological (MESH:D013312)
314 increased Appetite (MESH:D001066) 574: Increased, Appetite and hunger
316 increased increased susceptibility to viral infection (MP:0002418) 576: Increased, Viral susceptibility
322 increased acetylcholine receptor activator activity (GO:0030549) Nicotinic acetylcholine receptor (FMA:61796) 663: Desensitization, Nicotinic acetylcholine receptor
324 increased predatory behavior (GO:0002120)
329 increased Amputation, Congenital (MESH:C565682) 591: Increased, amputations
332 increased neurotransmitter secretion (GO:0007269) 600: Overactivation, Neuronotransmitter release
333 increased membrane depolarization (GO:0051899) 599: prolonged, Depolarization of neuronal membrane
334 increased locomotion (GO:0040011) 622: Increased, locomotion
335 increased fossorial locomotion behavior (NBO:0000071) 624: Increased, foot detachment
337 increased musculoskeletal movement (GO:0050881) valve (UBERON:0003978) 1142: Increased, valve movement