Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 301 to 325 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
294 decreased regulation of luteinizing hormone secretion (GO:0033684) Luteinizing hormone (CHEBI:81568) 531: Decreased, LH Surge
295 delayed abnormal ovulation (MP:0001928) 532: Delayed, Ovulation
296 decreased secretion (GO:0046903) cortical granule (GO:0060473) 533: Decreased, Cortical granule release/distribution upon fertilization
297 abnormal fertilization envelope (GO:0060387) 534: Altered, Formation of cortical envelope
298 abnormal sperm entry (GO:0035037) 535: Abnormal, Sperm penetration (polyspermy)
300 increased DNA hypermethylation (GO:0044026) 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
301 increased acetylcholine receptor activity (GO:0015464) Nicotinic acetylcholine receptor (FMA:61796) 559: Activation, Nicotinic acetylcholine receptor
302 abnormal foraging behavior (GO:0060756) 560: Abnormal, Foraging activity and behavior
304 abnormal binding (GO:0005488) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
305 abnormal signaling (GO:0023052) calmodulin (PR:000004978) 1243: Altered, Ca2+-calmodulin activated signal transduction
306 decreased reproductive behavior (GO:0019098) 565: Reduced, Brood care
307 abnormal thermoregulation behavior (NBO:0000051) 568: impaired, Hive thermoregulation
308 functional change response to wounding (GO:0009611) Mitochondrial deoxyribonucleic acid (FMA:67199) 570: Accumulation, Damaged mitochondrial DNA
309 premature aging (GO:0007568) 571: Accelerated, Aging
310 abnormal DNA repair (GO:0006281) Mitochondrial deoxyribonucleic acid (FMA:67199) 664: Overwhelmed, Mitochondrial DNA repair mechanisms
311 decreased population of organisms (PCO:0000001) 572: Decrease, Number of worker bees
314 increased Appetite (MESH:D001066) 574: Increased, Appetite and hunger
315 decreased abnormal maternal nurturing (MP:0001386) 565: Reduced, Brood care
316 increased increased susceptibility to viral infection (MP:0002418) 576: Increased, Viral susceptibility
317 abnormal developmental process (GO:0032502) 577: impaired, Development
318 decreased glucose oxidase activity (GO:0046562) D-glucono-1,5-lactone (CHEBI:16217) 578: Decreased, Glucose oxidase enzyme activity
319 decreased hydrogen peroxide biosynthetic process (GO:0050665) hydrogen peroxide (CHEBI:16240) 579: Decreased, Hydrogen peroxide production
321 abnormal calmodulin binding (GO:0005516) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
322 increased acetylcholine receptor activator activity (GO:0030549) Nicotinic acetylcholine receptor (FMA:61796) 663: Desensitization, Nicotinic acetylcholine receptor
323 decreased receptor regulator activity (GO:0030545) 663: Desensitization, Nicotinic acetylcholine receptor