Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 326 to 350 of 1152 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


345	increased		anesthesia (MESH:D000758)	634: N/A, sedation
352	increased		3',5'-cyclic AMP(1-) (CHEBI:58165)	693: Increased, cyclic adenosine monophosphate
359	increased	deactivation of mitotic spindle assembly checkpoint (GO:1902426)	MAD2 like protein (fruit fly) (PR:Q9VNE1)	695: Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
361	increased	Arrhythmias, Cardiac (MESH:D001145)		699: Increased, cardiac arrthymia
364	increased	cell death (GO:0008219)	kidney tubule cell (CL:1000507)	709: Increase, Cytotoxicity (renal tubular cell)
365	increased	epithelial cell proliferation (GO:0050673)	nephron tubule epithelial cell (CL:1000494)	None
366	increased		Adenoma (MESH:D000236)	9 Events 713: Increase, Adenomas/carcinomas (renal tubular) 719: Increase, hepatocellular adenomas and carcinomas 736: Increase, Adenomas/carcinomas (bronchioloalveolar) 741: Increase, Adenomas/carcinomas (follicular cell) 773: Increase, Endometrial adenocarcinomas 797: Increase, Adenomas/carcinomas (urothelial) 1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell) 1053: Promotion, ovarian adenomas 1079: Increased, Adenomas/carcinomas (mammary)
367	increased		Carcinoma (MESH:D002277)	10 Events 713: Increase, Adenomas/carcinomas (renal tubular) 719: Increase, hepatocellular adenomas and carcinomas 736: Increase, Adenomas/carcinomas (bronchioloalveolar) 741: Increase, Adenomas/carcinomas (follicular cell) 773: Increase, Endometrial adenocarcinomas 779: Increase, Papillomas/carcinomas (squamous cells) 797: Increase, Adenomas/carcinomas (urothelial) 1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell) 1063: Increased, Pancreatic acinar tumors 1079: Increased, Adenomas/carcinomas (mammary)
368	increased	hyperplasia (MESH:D006965)	kidney tubule cell (CL:1000507)	767: Increase, Hyperplasia (renal tubular cells)
369	increased		major urinary protein (rat) (PR:P02761)	708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
370	increased	binding (GO:0005488)	major urinary protein (rat) (PR:P02761)	714: Increased, Binding of chemicals to 2u (serum)
372	increased	tubulin binding (GO:0015631)	tubulin (PR:000028799)	718: Binding, Tubulin
373	increased	microtubule depolymerization (GO:0007019)	microtubule (GO:0005874)	720: Disruption, Microtubule dynamics
375	increased	cell proliferation (GO:0008283)	mitogenic signaling cell (CL:0000422)	716: Increase, cell proliferation (hepatocytes)
376	increased	preneoplasia (MP:0002009)	abnormal cell mass (MP:0003902)	774: Increase, Preneoplastic foci (hepatocytes)
378	increased	cellular respiration (GO:0045333)		769: Increase, Oxidative metabolism
379	increased	pyruvate dehydrogenase activity (GO:0004738)	pyruvate dehydrogenase [ubiquinone] (PR:000023575)	726: Increased, Induction of pyruvate dehydrogenase (PDH)
381	increased	cell death (GO:0008219)	bronchial epithelial cell (CL:0002328)	733: Increase, Necrosis (terminal bronchiolar cells)
382	increased	epithelial cell proliferation (GO:0050673)	bronchial epithelial cell (CL:0002328)	734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)
383	increased	hyperplasia (MESH:D006965)	bronchial epithelial cell (CL:0002328)	735: Increase, Hyperplasia (terminal bronchiolar cells)
384	increased	cell death (GO:0008219)	Clara cell (CL:0000158)	770: Increase, Cytotoxicity (club cells)
385	increased	cell proliferation (GO:0008283)	thyroid follicular cell (CL:0002258)	2 Events 739: Increase, Hypertrophy and proliferation (follicular cell) 1024: Increased, Hypertrophy and proliferation (follicular cell)
386	increased	hypertrophy (MESH:D006984)	thyroid follicular cell (CL:0002258)	2 Events 739: Increase, Hypertrophy and proliferation (follicular cell) 1024: Increased, Hypertrophy and proliferation (follicular cell)
387	increased	hyperplasia (MESH:D006965)	thyroid follicular cell (CL:0002258)	2 Events 740: Increase, Hyperplasia (follicular cells) 1025: Increased, Hyperplasia (follicular cells)
388	increased		Thyroid stimulating hormone (CHEBI:81567)	2 Events 753: Increase, Thyroid-stimulating hormone (TSH) 1023: Increased, Thyroid-stimulating hormone (TSH)