Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 326 to 350 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
811 increased glycosylation (GO:0070085) mucin-5AC (PR:000031343) 1910: Mucus Viscosity, Increased
479 increased gene expression (GO:0010467) mucin-5AC (PR:000031343) 962: Increase, Mucin production
480 increased secretion (GO:0046903) mucin-5AC (PR:000031343) None
20 decreased transmission of nerve impulse (GO:0019226) motor neuron (CL:0000100) 1267: Decrease, Ecdysis motor program activity
801 decreased Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) None
802 occurrence Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) 1908: Cilia Beat Frequency, Decreased
807 decreased motile cilium (GO:0031514) 1912: Motile Cilia Number/Length, Decreased
1014 decreased thyroid hormone transport (GO:0070327) monocarboxylate transporter 8 (PR:000014950) 2258: Inhibition, monocarboxylate transporter 8 (MCT8)
375 increased cell proliferation (GO:0008283) mitogenic signaling cell (CL:0000422) 716: Increase, cell proliferation (hepatocytes)
795 decreased mitochondrion (GO:0005739) None
796 decreased ATP synthesis coupled proton transport (GO:0015986) mitochondrion (GO:0005739) None
797 increased oxidative phosphorylation uncoupler activity (GO:0017077) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
798 decreased regulation of mitochondrial membrane potential (GO:0051881) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
799 increased proton binding (GO:1901691) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
6 functional change mitochondrion (GO:0005739)
177 functional change mitochondrion disassembly (GO:0061726) mitochondrion (GO:0005739) None
664 decreased function (MI:0613) mitochondrion (GO:0005739) 1260: Direct mitochondrial inhibition
1086 decreased cytochrome-c oxidase activity (GO:0004129) mitochondrion (GO:0005739) 1840: Inhibition, cytochrome oxidase
1115 decreased Decreased activity of mitochondrial complex III (HP:0011924) mitochondrial respiratory chain complex III (GO:0005750) 1542: Inhibition, Mitochondrial complex III
118 disrupted mitochondrial respiratory chain (GO:0005746) 178: Mitochondrial electron transport chain, disrupted
308 functional change response to wounding (GO:0009611) Mitochondrial deoxyribonucleic acid (FMA:67199) 570: Accumulation, Damaged mitochondrial DNA
310 abnormal DNA repair (GO:0006281) Mitochondrial deoxyribonucleic acid (FMA:67199) 664: Overwhelmed, Mitochondrial DNA repair mechanisms
373 increased microtubule depolymerization (GO:0007019) microtubule (GO:0005874) 720: Disruption, Microtubule dynamics
258 increased signaling (GO:0023052) microsomal triglyceride transfer protein large subunit MTTP (PR:000003392) 879: Activation, MTTP
8 pathological brain inflammation (MP:0001847) microglial cell (CL:0000129) 188: Neuroinflammation