Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 326 to 350 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
598 increased oxidative phosphorylation uncoupler activity (GO:0017077) 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
632 increased oxidation-reduction process (GO:0055114) plasma membrane (GO:0005886) 1238: Activation of oxidative stress pathway
633 increased oxidation-reduction process (GO:0055114) protein (PR:000000001) 1238: Activation of oxidative stress pathway
634 increased oxidation-reduction process (GO:0055114) deoxyribonucleic acid (CHEBI:16991) 1238: Activation of oxidative stress pathway
511 abnormal ovulation cycle (GO:0042698) 971: Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
36 disrupted ovulation cycle (GO:0042698) None
1063 disrupted ovulation cycle (GO:0042698) ovarian follicle (UBERON:0001305) 405: disrupted, ovarian cycle
1065 decreased ovulation (GO:0030728) Ovum (FMA:67343) 1695: Impaired ovulation
262 decreased ovulation (GO:0030728) 488: Decrease, Ovulation
1061 decreased ovarian follicle development (GO:0001541) ovarian follicle (UBERON:0001305) 1883: Decreased, size of the ovarian reserve
1094 decreased ovarian follicle development (GO:0001541) granulosa cell (CL:0000501) 1800: Granulosa cell proliferation of gonadotropin-independent follicles, Reduced
825 abnormal otic vesicle formation (GO:0030916) 1930: altered, inner ear development
599 increased osteoporosis (MP:0000066) 1151: Osteoporosis and vascular calcification, Bone deterioration
1005 increased osteoclast differentiation (GO:0030316) 2089: Altered Bone Cell Homeostasis
1004 decreased osteoblast differentiation (GO:0001649) 2089: Altered Bone Cell Homeostasis
470 occurrence organelle disassembly (GO:1903008) lysosome (GO:0005764) 898: Disruption, Lysosome
112 decreased oocyte growth (GO:0001555) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
113 decreased oocyte development (GO:0048599) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
657 increased offspring quantity (VT:1000189) 1208: Increased, Male offspring
950 occurrence nuclear export (GO:0051168) viral genome (GO:0019015) None
291 decreased norepinephrine biosynthetic process (GO:0042421) (R)-noradrenaline (CHEBI:18357) 528: Decreased, Synthesis of NE
434 decreased norepinephrine binding (GO:0051380) (R)-noradrenaline (CHEBI:18357) 848: Decreased, Binding of NE to NE receptors on GnRH neurons
1100 increased NMDA glutamate receptor activity (GO:0004972) None
685 decreased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 195: Inhibition, NMDARs
686 increased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 388: Overactivation, NMDARs