Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 351 to 375 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
390 increased Leydig cell hyperplasia (MP:0001152) Leydig cell (CL:0000178) 744: Increase, Hyperplasia (Leydig cells)
391 increased neoplasm (MP:0002006) 745: Increase, Leydig cell tumors
392 increased Luteinizing hormone (CHEBI:81568)
395 increased synaptic transmission, dopaminergic (GO:0001963) 746: Increase, Dopaminergic activity
396 increased endometrium hyperplasia (MP:0009092) glandular cell of endometrium (CL:0002656) 772: Increase, Hyperplasia (glandular epithelial cells of endometrium)
397 increased chloride channel activity (GO:0005254) glutamate-gated chloride channel (fruit fly) (PR:Q94900)
399 increased chloride transmembrane transport (GO:1902476) chloride (CHEBI:17996) 761: Increased, Chloride conductance
400 increased membrane hyperpolarization (GO:0060081) 763: hyperpolarisation, neuron
401 increased cell death (GO:0008219) corneal epithelial cell (CL:0000575) 776: Increase, Cytotoxicity (corneal cells)
402 increased inflammatory response (GO:0006954) corneal epithelial cell (CL:0000575) 777: Increase, Inflammation (corneal cells)
403 increased cell proliferation (GO:0008283) corneal epithelial cell (CL:0000575) 778: Increase, Regenerative cell proliferation (corneal cells)
404 increased papilloma (MESH:D010212) 779: Increase, Papillomas/carcinomas (squamous cells)
405 increased tyrosine (CHEBI:18186) 775: Increased, Plasma tyrosine
407 increased cell death (GO:0008219) epithelial cell (CL:0000066) 780: Increase, Cytotoxicity (epithelial cells)
408 increased cell proliferation (GO:0008283) epithelial cell (CL:0000066)
409 increased stomach epithelial hyperplasia (MP:0005493) epithelial cell (CL:0000066) 782: Increase, Hyperplasia (forestomach epithelial cells)
410 increased Carcinoma, Renal Cell (MESH:D002292) Adenoma (MESH:D000236) 713: Increase, Adenomas/carcinomas (renal tubular)
411 increased cell death (GO:0008219) nephron tubule epithelial cell (CL:1000494) 783: Increase, Cytotoxicity (tubular epithelial cells)
412 increased kidney epithelium hyperplasia (MP:0004968) nephron tubule epithelial cell (CL:1000494) 784: Increase, Hyperplasia (tubular epithelial cells)
413 increased hepatocellular carcinoma (MESH:D006528) Adenoma (MESH:D000236) 719: Increase, hepatocellular adenomas and carcinomas
414 increased cell death (GO:0008219) hepatocyte (CL:0000182) 786: Increase, Cytotoxicity (hepatocytes)
415 increased cell proliferation (GO:0008283) hepatocyte (CL:0000182) 787: Increase, Regenerative cell proliferation (hepatocytes)
417 increased increased thyroid-stimulating hormone level (MP:0005135) Thyroid stimulating hormone (CHEBI:81567) 753: Increase, Thyroid-stimulating hormone (TSH)
419 increased cystolithiasis (MP:0011625) Calculi (MESH:D002137) 793: Increase, Urinary bladder calculi
420 increased cell death (GO:0008219) urothelial cell (CL:0000731) 794: Increase, Cytotoxicity (urothelial cells)