Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 351 to 375 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
428 decreased mevalonate (CHEBI:25350) 805: Decreased, mevalonate
154 increased Methemoglobinemia (MESH:D008708) 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
1120 decreased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 968: Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons
1136 decreased neuropeptide signaling pathway (GO:0007218) Metastin (CHEBI:80304) None
1138 increased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 1985: Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)
509 decreased neurotransmitter secretion (GO:0007269) metastasis-suppressor KiSS-1 (rat) (PR:Q7TSB7) None
556 morphological change Metaplasia (MESH:D008679) None
462 increased Metaplasia (MESH:D008679) 869: Increase, Respiratory or Squamous Metaplasia
158 increased metabolic process (GO:0008152) metabolite (CHEBI:25212) 77: Production, Critical Metabolites (CGA 330050 and CGA 265307)
572 increased cell proliferation (GO:0008283) mesothelium (UBERON:0001136) 1089: Increased, Cell Proliferation (mesothelium)
573 increased mesothelioma (MESH:D008654) None
871 increased Malignant mesothelioma (HP:0100001) mesothelioma (MESH:D008654) 1090: Increased, mesotheliomas
865 increased cell proliferation (GO:0008283) mesothelial cell (CL:0000077) 870: Increase, Cell Proliferation
533 increased mesenchymal cell proliferation (GO:0010463) mesenchymal cell (CL:0008019) 1033: Increased, proliferation of mesenchymal cells
204 increased cell proliferation (GO:0008283) memory T cell (CL:0000813) 272: Activation/Proliferation, T-cells
179 increased membrane (GO:0016020) 46: Accumulation, Biological membranes
733 abnormal Abnormal spermatogenesis (HP:0008669) Mature sperm cell (FMA:67338) 1758: Impaired, Spermatogenesis
602 decreased carboxylation reaction (MI:1139) matrix Gla protein (mouse) (PR:P19788) 1169: Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
668 increased signaling (GO:0023052) map kinase p38 (PR:000003106) 1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK
570 increased hyperplasia (MESH:D006965) mammary gland (UBERON:0001911) 1085: Increased, hyperplasia (mammary gland)
431 morphological change male reproductive system (UBERON:0000079) 809: malformed, Male reproductive tract
659 increased male reproductive organ (UBERON:0003135) 1209: Induction, Male reproductive tract
95 morphological change male reproductive organ (UBERON:0003135) 348: Malformation, Male reproductive tract
98 arrested developmental process (GO:0032502) male reproductive organ (UBERON:0003135) 240: Feminisation or incomplete development, Primary and accessory male sex organs
658 increased male organism (UBERON:0003101) 1208: Increased, Male offspring