Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 376 to 400 of 1152 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


369	increased		major urinary protein (rat) (PR:P02761)	708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
370	increased	binding (GO:0005488)	major urinary protein (rat) (PR:P02761)	714: Increased, Binding of chemicals to 2u (serum)
359	increased	deactivation of mitotic spindle assembly checkpoint (GO:1902426)	MAD2 like protein (fruit fly) (PR:Q9VNE1)	695: Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
715	increased	macrophage activation involved in immune response (GO:0002281)	macrophage (CL:0000235)	1394: Induction, persistent proliferation/sustained proliferation
720	decreased	phagocytosis (GO:0006909)	macrophage (CL:0000235)	1668: Frustrated phagocytosis
858	increased	macrophage activation (GO:0042116)	macrophage (CL:0000235)	1497: Increased, recruitment of inflammatory cells
451	functional change		lysosome (GO:0005764)	831: Disturbance, Lysosomal function
470	occurrence	organelle disassembly (GO:1903008)	lysosome (GO:0005764)	898: Disruption, Lysosome
709	increased	endocytosis (GO:0006897)	lysosomal membrane (GO:0005765)	1539: Endocytotic lysosomal uptake
1021	increased		lysophosphatidylcholine (CHEBI:60479)	2263: Lysolecithin, increased
838	decreased	Lymphopenia (HP:0001888)	lymphocyte (CL:0000542)	1868: Hyperinflammation
68	decreased		lymphocyte (CL:0000542)	168: Decreased, Lymphocytes
114	decreased		Luteinizing hormone (CHEBI:81568)	2 Events 129: Reduction, Gonadotropins, circulating concentrations 690: Reduced, Luteinizing hormone (LH), plasma
230	increased	hormone biosynthetic process (GO:0042446)	Luteinizing hormone (CHEBI:81568)	414: Increase, Luteinizing hormone (LH)
294	decreased	regulation of luteinizing hormone secretion (GO:0033684)	Luteinizing hormone (CHEBI:81568)	531: Decreased, LH Surge
392	increased		Luteinizing hormone (CHEBI:81568)	2 Events 754: Increased, Luteinizing hormone (LH) 791: Increased, Leutinizing hormone (LH)
433	decreased	hormone secretion (GO:0046879)	Luteinizing hormone (CHEBI:81568)	2 Events 531: Decreased, LH Surge 1072: Decreased, LH Surge from anterior pituitary
510	decreased	luteinizing hormone secretion (GO:0032275)	Luteinizing hormone (CHEBI:81568)	2 Events 970: Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs 1050: Increased, secretion of LH from anterior pituitary
805	increased	mucus secretion (GO:0070254)	lung goblet cell (CL:1000143)	1251: Chronic, Mucus hypersecretion
866	increased	Neoplasm of the lung (HP:0100526)	lung (UBERON:0002048)	1670: Lung cancer
867	increased	increased lung tumor incidence (MP:0008014)	lung (UBERON:0002048)	1670: Lung cancer
1089	increased	Pulmonary edema (HP:0100598)	lung (UBERON:0002048)	2316: Increased, pulmonary edema
241	increased	gene expression (GO:0010467)	low-density lipoprotein receptor (PR:000009744)	466: Up Regulation, LDLR (low density lipoprotein receptor)
1048	increased	increased circulating LDL cholesterol level (MP:0000182)	low-density lipoprotein cholesterol (CHEBI:47774)	2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
242	increased	receptor-mediated endocytosis (GO:0006898)	low-density lipoprotein (CHEBI:39026)	467: Increased, LDL uptake