Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 426 to 450 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
229 increased ionotropic glutamate receptor activity (GO:0004970) ionotropic glutamate receptor complex (GO:0008328) 875: Binding of agonist, Ionotropic glutamate receptors
416 decreased catalytic activity (GO:0003824) iodotyrosine deiodinase 1 (mouse) (PR:Q9DCX8) 788: Decrease, Incorporation of active iodide into iodotyrosines
603 decreased catalytic activity (GO:0003824) iodotyrosine deiodinase 1 (human) (PR:Q6PHW0) 1152: Inhibition, Iodotyrosine deiodinase (IYD)
236 decreased iodide transport (GO:0015705) iodide (CHEBI:16382)
211 increased hyperplasia (MESH:D006965) intrahepatic bile duct epithelial cell (CL:0002538) 854: Alterations, Cellular proliferation / hyperplasia
1040 increased Celiac disease (HP:0002608) intestinal epithelial cell (CL:0002563) None
1050 pathological Celiac disease (HP:0002608) intestinal epithelial cell (CL:0002563) 2257: Celiac disease
627 increased cytokine production (GO:0001816) interleukin-8 (PR:000001395) 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation
827 increased Increased inflammatory response (HP:0012649) interleukin-6 (PR:000001393) None
831 increased interleukin-6 production (GO:0032635) interleukin-6 (PR:000001393) 1868: Hyperinflammation
519 decreased interleukin-4 production (GO:0032633) interleukin-4 (PR:000001391)
518 decreased interleukin-2 production (GO:0032623) interleukin-2 (PR:000001379) 1202: Suppression, IL-2 and IL-4 production
978 decreased interleukin-1 receptor activity (GO:0004908) interleukin-1 receptor type I (PR:000001363) 1700: Impaired IL-1R1 signaling in T cell
829 increased Increased inflammatory response (HP:0012649) interleukin-1 beta (PR:000001136) None
832 increased interleukin-1 beta production (GO:0032611) interleukin-1 beta (PR:000001136) 1868: Hyperinflammation
856 increased Interleukin (FMA:86578) 1496: Increased, secretion of proinflammatory mediators
933 occurrence inhibition of host DNA replication by virus (GO:0098673) interferon regulatory factor 3 complex (GO:0097072) None
879 decreased type I interferon signaling pathway (GO:0060337) interferon beta (PR:000024939) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
878 decreased type I interferon signaling pathway (GO:0060337) interferon alpha (PR:000024938) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
1045 decreased insulin-induced gene 1 protein (PR:000009056) None
1047 decreased decreased circulating total protein level (MP:0005567) insulin-induced gene 1 protein (PR:000009056) 2268: Decreased, insulin-induced gene 1 (INSIG1) protein activity
937 decreased toll-like receptor 7 signaling pathway (GO:0034154) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
938 decreased toll-like receptor 3 signaling pathway (GO:0034138) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
931 occurrence receptor-mediated endocytosis (GO:0006898) influenzavirus hemagglutinin (PR:000049750) 2159: Influenza A virus (IAV) cell entry
947 occurrence membrane fusion (GO:0061025) influenzavirus hemagglutinin (PR:000049750) None