Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 51 to 75 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
738 occurrence secondary generalized seizure (NBO:0000703) brain (UBERON:0000955) 1788: Status epilepticus
773 occurrence regulation of cellular response to drug (GO:2001038) 1651: Treatment-resistant gastric cancer
178 occurrence fatty liver (MESH:D005234) 345: N/A, Liver Steatosis
929 occurrence receptor-mediated endocytosis (GO:0006898) clathrin-coated vesicle membrane (GO:0030665) None
945 occurrence vesicle targeting, plasma membrane to endosome (GO:0048201) None
447 occurrence Mallory bodies (MP:0014045) 839: Formation, Mallory body
662 occurrence Translocation, Genetic (MESH:D014178) 1253: MLL chromosomal translocation
880 occurrence cellular response to exogenous dsRNA (GO:0071360) RNA viral genome (GO:0019022) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
909 occurrence viral entry into host cell (GO:0046718) viral protein (PR:000036197) 1738: SARS-CoV-2 cell entry
766 occurrence regulation of response to reactive oxygen species (GO:1901031) reactive oxygen species (CHEBI:26523) 1634: Increase, Oxidative DNA damage
87 occurrence oxidative stress (MP:0003674) None
445 occurrence podocyte vacuolization (MP:0011899) 824: Occurrence, Cytoplasmic vacuolization (podocyte)
475 occurrence transdifferentiation (GO:0060290) ciliated epithelial cell (CL:0000067) 919: Occurrence, Transdifferentiation of ciliated epithelial cells
477 occurrence hyperplasia (MESH:D006965) goblet cell (CL:0000160) 921: Occurrence, Hyperplasia of goblet cells
450 occurrence autophagic cell death (GO:0048102)
11 occurrence Parkinsonian disorders (MESH:D020734) 896: Parkinsonian motor deficits
192 occurrence liver fibrosis (MP:0003333) liver (UBERON:0002107)
50 occurrence membrane depolarization (GO:0051899) 616: Occurrence, A paroxysmal depolarizing shift
944 occurrence clathrin-dependent endocytosis (GO:0072583) None
953 occurrence suppression by virus of host cytokine production (GO:0046775) 2180: Immune mechanisms antagonized by viral proteins
955 occurrence modulation by virus of host immune response (GO:0075528) 2180: Immune mechanisms antagonized by viral proteins
946 occurrence pH reduction (GO:0045851) endosome (GO:0005768) None
877 occurrence endocytosis involved in viral entry into host cell (GO:0075509) cathepsin L1 (human) (PR:P07711) 1738: SARS-CoV-2 cell entry
930 occurrence protein localization to endosome (GO:0036010) clathrin-coated vesicle membrane (GO:0030665) 2159: Influenza A virus (IAV) cell entry
932 occurrence membrane fusion (GO:0061025) vesicle membrane (GO:0012506) 2159: Influenza A virus (IAV) cell entry