Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 51 to 75 of 1147 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


63	decreased	synaptic signaling (GO:0099536)		2 Events 386: Decrease of neuronal network function 618: Decreased, Neuronal network function in adult brain
49	decreased	GABA-gated chloride ion channel activity (GO:0022851)	chloride (CHEBI:17996)	2 Events 64: Reduction, Ionotropic GABA receptor chloride channel conductance 762: Activation, ionotropic GABA Receptor chloride channel
175	increased	fatty acid biosynthetic process (GO:0006633)	fatty acid (CHEBI:35366)	2 Events 89: Synthesis, De Novo Fatty Acid (FA) 458: Increased, De Novo FA synthesis
6	functional change		mitochondrion (GO:0005739)	2 Events 177: Increase, Mitochondrial dysfunction 2363: Elevated mitochondrial ROS and dysfunction
207	decreased	apoptotic process (GO:0006915)		2 Events 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis 1183: Decreased, Apoptosis (Epithelial Cells)
183	decreased	peroxisome proliferator activated receptor signaling pathway (GO:0035357)	peroxisome proliferator-activated receptor gamma (PR:000013058)	2 Events 233: Decreased, PPAR-gamma activation 1028: Activation of specific nuclear receptors, PPAR-gamma activation
151	increased		erythrocyte (CL:0000232)	2 Events 246: Increase, RBC congestion in liver 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
275	decreased	receptor transactivation (GO:0035624)	COUP transcription factor 2 (PR:000011405)	2 Events 656: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) 541: Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
325	decreased	sodium channel inhibitor activity (GO:0019871)	sodium channel protein type 1 subunit alpha (PR:000002095)	2 Events 584: Inhibition, sodium channel 598: modulation, sodium channel
132	decreased		prostaglandin E2 (CHEBI:15551)	2 Events 243: Reduction, Prostaglandin E2 concentration 687: Reduced, Prostaglandin E2 concentration, hypothalamus
15	increased	muscle contraction (GO:0006936)		2 Events 993: Decrease, Abdominal muscle contraction 601: Overactivation, muscle contraction
174	increased	gene expression (GO:0010467)	acyl-CoA desaturase (PR:000014497)	2 Events 258: Activation, SCD-1 462: Up Regulation, SCD-1
227	increased	hepatocyte proliferation (GO:0072574)	hepatocyte (CL:0000182)	2 Events 491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) 716: Increase, cell proliferation (hepatocytes)
186	decreased	3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857)	3-hydroxyacyl-CoA dehydrogenase type-2 (PR:000008774)	2 Events 8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity 1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene
27	decreased	ketosis (MESH:D007662)		2 Events 861: Decreased, Ketogenesis (production of ketone bodies) 477: Decreased, Ketogenesis
347	decreased	prostaglandin biosynthetic process (GO:0001516)	prostaglandin F2alpha (CHEBI:15553)	2 Events 672: Reduced, Prostaglandin F2alpha synthesis, ovary 681: Decreased, Prostaglandin F2alpha synthesis, ovary
327	decreased	aquatic locomotion (NBO:0000371)		2 Events 586: Reduced, swimming speed 1005: Reduced, Swimming performance
34	decreased	estrogen biosynthetic process (GO:0006703)	17beta-estradiol (CHEBI:16469)	2 Events 3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells 1789: Reduction, 17beta-estradiol synthesis by the undifferentiated gonad
37	increased	signaling (GO:0023052)	nuclear receptor subfamily 1 group I member 2 (PR:000011397)	2 Events 239: Activation, Pregnane-X receptor, NR1I2 245: Activation, PXR/SXR
139	increased	gene expression (GO:0010467)	vitellogenins (MESH:D014819)	2 Events 307: Increase, Vitellogenin synthesis in liver 418: Increased, Vitellogenin synthesis
96	decreased	androgen receptor activity (GO:0004882)	androgen receptor (PR:000004191)	2 Events 26: Antagonism, Androgen receptor 1614: Decrease, androgen receptor activation
167	increased	signaling (GO:0023052)	oxysterols receptor LXR-alpha (PR:000011395)	2 Events 167: Activation, LXR 483: Activation, LXR alpha
253	increased	biosynthetic process (GO:0009058)	triglyceride (CHEBI:17855)	2 Events 454: Increased, Triglyceride formation 881: Increased, Triglyceride
233	increased	hemorrhage (MP:0001914)		2 Events 421: Increased, glomerular rupture and renal hemorrhaging 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
303	increased	colony collapse (MESH:D056631)		2 Events 563: Death/Failure, Colony 1107: Weakened, Colony