Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 851 to 875 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
393 decreased Prolactin (CHEBI:81580) 747: Decreased, Prolactin
394 decreased progesterone secretion (GO:0042701) progesterone (CHEBI:17026) 749: Decreased, Progesterone from corpus luteum
398 decreased population quality (PCO:0000003) 765: Decreased, population 1
406 decreased 4-hydroxyphenylpyruvate dioxygenase activity (GO:0003868) 4-hydroxyphenylpyruvate dioxygenase (rat) (PR:P32755) 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
416 decreased catalytic activity (GO:0003824) iodotyrosine deiodinase 1 (mouse) (PR:Q9DCX8) 788: Decrease, Incorporation of active iodide into iodotyrosines
418 decreased catalytic activity (GO:0003824) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (rat) (PR:P31214) None
423 decreased aromatase activity (GO:0070330) aromatase isoform 1 (PR:000038849) 800: Decreased, Aromatase (Cyp19a1) mRNA
425 decreased catalytic activity (GO:0003824) Prolyl hydroxylases (MESH:D064828) 798: Inhibition, Prolyl hydroxylases
428 decreased mevalonate (CHEBI:25350) 805: Decreased, mevalonate
429 decreased cholesterol (CHEBI:16113) None
430 decreased hydroxymethylglutaryl-CoA reductase activity (GO:0042282) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (PR:000008636) 804: Inhibition, HMG-CoA reductase
432 decreased reduced fertility (MP:0001921) fertility (MESH:D005298) 527: Decreased, Decreased fecundity
433 decreased hormone secretion (GO:0046879) Luteinizing hormone (CHEBI:81568)
434 decreased norepinephrine binding (GO:0051380) (R)-noradrenaline (CHEBI:18357) 848: Decreased, Binding of NE to NE receptors on GnRH neurons
435 decreased signaling (GO:0023052) alpha-2A adrenergic receptor (PR:000001186) 849: Inhibition, Antgonism of NE receptor
436 decreased glomerular filtration (GO:0003094) 819: Decreased, Glomerular filtration
437 decreased kidney plasma flow trait (VT:0005524) 820: Decreased, Renal plasma flow
438 decreased renal absorption (GO:0070293) sodium(1+) (CHEBI:29101) 821: Decreased, Sodium reabsorption
439 decreased function (MI:0613) kidney (UBERON:0002113) 825: Decreased, Renal ability to dilute urine
449 decreased phospholipase activity (GO:0004620) phospholipase A1 member A (human) (PR:Q53H76) 828: Inhibition, Phospholipase A
455 decreased catalytic activity (GO:0003824) uroporphyrinogen decarboxylase (PR:000017134) 845: Inhibition, UROD
458 decreased regulation of intracellular pH (GO:0051453) 867: Decrease, Intracellular pH
464 decreased signaling (GO:0023052) solute carrier family 22 member 6 (PR:000014993) 877: Inhibition, organic anion transporter 1 (OAT1)
474 decreased epithelial cell apoptotic process (GO:1904019) None
481 decreased respiratory function trait (VT:0002327) 1250: Decrease, Lung function