Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 876 to 900 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
483 decreased biosynthetic process (GO:0009058) 5,6,7,8-tetrahydrobiopterin (CHEBI:15372) 934: KE3 : Decrease, Tetrahydrobiopterin
484 decreased proteasome complex disassembly (GO:1903009) GTP cyclohydrolase 1 (PR:000007893) 935: KE2 : Decrease, GTPCH-1
485 decreased catalytic activity (GO:0003824) nitric oxide synthase, endothelial (PR:000011328) 973: KE5 : Decrease, AKT/eNOS activity
486 decreased catalytic activity (GO:0003824) AKT kinase (PR:000029189) 973: KE5 : Decrease, AKT/eNOS activity
487 decreased nitric oxide biosynthetic process (GO:0006809) nitric oxide (CHEBI:16480) 933: KE6 : Depletion, Nitric Oxide
498 decreased gene expression (GO:0010467) vascular endothelial growth factor A (PR:000017284) 948: reduced production, VEGF
501 decreased protein dimerization activity (GO:0046983) hypoxia-inducible factor 1-alpha (PR:000008555) 945: reduced dimerization, ARNT/HIF1-alpha
502 decreased protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) 945: reduced dimerization, ARNT/HIF1-alpha
507 decreased signaling (GO:0023052) aromatase (PR:000006100) 964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
508 decreased estrogen (CHEBI:50114) None
509 decreased neurotransmitter secretion (GO:0007269) metastasis-suppressor KiSS-1 (rat) (PR:Q7TSB7) None
510 decreased luteinizing hormone secretion (GO:0032275) Luteinizing hormone (CHEBI:81568)
513 decreased cytokine production involved in inflammatory response (GO:0002534) NFAT activation molecule 1 (PR:000011161) 981: Reduction, NFAT/AP-1 complex formation
518 decreased interleukin-2 production (GO:0032623) interleukin-2 (PR:000001379) 1202: Suppression, IL-2 and IL-4 production
519 decreased interleukin-4 production (GO:0032633) interleukin-4 (PR:000001391)
520 decreased 3,3',5-triiodo-L-thyronine (CHEBI:18258)
521 decreased catalytic activity (GO:0003824) type II iodothyronine deiodinase (PR:000006481) 1002: Inhibition, Deiodinase 2
522 decreased swim bladder inflation (GO:0048798) posterior chamber swim bladder (UBERON:2001278) 1004: Reduced, Posterior swim bladder inflation
523 decreased survival (MESH:D013534) None
524 decreased swim bladder inflation (GO:0048798) anterior chamber swim bladder (UBERON:2001277) 1007: Reduced, Anterior swim bladder inflation
525 decreased sensory perception of sound (GO:0007605) 1008: Reduced, Hearing
526 decreased catalytic activity (GO:0003824) type I iodothyronine deiodinase (PR:000006480) 1009: Inhibition, Deiodinase 1
528 decreased negative regulation of synaptic transmission (GO:0050805) GABA receptor complex (GO:1902710) 1015: Increased, Neuronal synaptic inhibition
544 decreased estradiol (CHEBI:23965) 1045: Decreased, Ovarian E2
545 decreased follicle-stimulating hormone secretion (GO:0046884) Follicle stimulating hormone (CHEBI:81569) 1049: Increased, secrection of FSH from anterior pituitary