Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 876 to 900 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
314 increased Appetite (MESH:D001066) 574: Increased, Appetite and hunger
315 decreased abnormal maternal nurturing (MP:0001386) 565: Reduced, Brood care
316 increased increased susceptibility to viral infection (MP:0002418) 576: Increased, Viral susceptibility
317 abnormal developmental process (GO:0032502) 577: impaired, Development
320 decreased feeding behavior (NBO:0000079)
323 decreased receptor regulator activity (GO:0030545) 663: Desensitization, Nicotinic acetylcholine receptor
324 increased predatory behavior (GO:0002120)
326 decreased action potential (GO:0001508) 585: Decreased, Sodium conductance 1
327 decreased aquatic locomotion (NBO:0000371)
328 decreased life span trait (VT:0005372)
330 decreased hypoxia (MP:0005039) 590: N/A, hypoxia
332 increased neurotransmitter secretion (GO:0007269) 600: Overactivation, Neuronotransmitter release
333 increased membrane depolarization (GO:0051899) 599: prolonged, Depolarization of neuronal membrane
334 increased locomotion (GO:0040011) 622: Increased, locomotion
335 increased fossorial locomotion behavior (NBO:0000071) 624: Increased, foot detachment
339 decreased fear/anxiety related behavior (NBO:0000018) 627: Decreased, anxiety
340 decreased abnormal sheltering behavior (MP:0014039) 629: Decreased, sheltering
344 decreased locomotion (GO:0040011) 635: Decreased, locomotion
349 decreased attraction-related behavior (NBO:0000280) 674: Reduced, Ability to attract spawning mates
350 decreased reproduction (GO:0000003)
356 decreased G2/MI transition of meiotic cell cycle (GO:0008315) 694: Reduced, Meiotic prophase I/metaphase I transition, oocyte
357 abnormal chromosome segregation (GO:0007059) 696: Increased, Chromosome misseggregation
360 abnormal action potential (GO:0001508) 698: Altered, Action Potential
361 increased Arrhythmias, Cardiac (MESH:D001145) 699: Increased, cardiac arrthymia
377 abnormal regulation of gene expression (GO:0010468) 1214: Altered gene expression specific to CAR activation, Hepatocytes