Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 876 to 900 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
54 decreased calcium ion transport (GO:0006816) calcium ion (CHEBI:39124)
615 increased calcium ion transport (GO:0006816) calcium ion (CHEBI:39124)
922 increased calcium amount (VT:0010499) calcium(2+) (CHEBI:29108) 1339: Increase, intracellular calcium
958 increased Breast carcinoma (HP:0003002) VEGF-A complex (GO:1990150) 1376: Increase, angiogenesis
959 increased Breast carcinoma (HP:0003002) BRCA1-A complex (GO:0070531) 1971: Increased, tumor growth
8 pathological brain inflammation (MP:0001847) microglial cell (CL:0000129) 188: Neuroinflammation
9 pathological brain inflammation (MP:0001847) astrocyte (CL:0000127) 188: Neuroinflammation
707 morphological change brain development (GO:0007420) hippocampal formation (UBERON:0002421) 757: Hippocampal anatomy, Altered
1001 decreased bone mineralization (GO:0030282) 2090: Increase, Bone Remodeling
989 increased blood viscosity trait (VT:3000004) blood (UBERON:0000178) 2238: Increased, Blood viscosity
900 occurrence blood vessel remodeling (GO:0001974) blood vessel (UBERON:0001981) 2069: Occurrence, Abnormal Vascular Remodeling
915 increased blood coagulation, fibrin clot formation (GO:0072378) Fibrin (CHEBI:5054) 1846: Thrombosis and Disseminated Intravascular Coagulation
221 decreased blood circulation (GO:0008015) blood (UBERON:0000178) 298: Insufficiency, Vascular
1018 decreased blood circulation (GO:0008015) blood plasma (UBERON:0001969) 2261: Decreased, blood plasma volume
253 increased biosynthetic process (GO:0009058) triglyceride (CHEBI:17855)
483 decreased biosynthetic process (GO:0009058) 5,6,7,8-tetrahydrobiopterin (CHEBI:15372) 934: KE3 : Decrease, Tetrahydrobiopterin
667 increased biosynthetic process (GO:0009058) reactive oxygen species (CHEBI:26523) None
503 increased binding (GO:0005488) transthyretin (PR:000016801) 957: Binding, Transthyretin in serum
515 increased binding (GO:0005488) FK506-binding protein 15 (PR:000007535) 980: Inhibition, Calcineurin Activity
516 increased binding (GO:0005488) FKBP12 (Arabidopsis thaliana) (TAIR:AT5G64350) 980: Inhibition, Calcineurin Activity
517 increased binding (GO:0005488) Immunophilins (MESH:D020104) 1201: Binding, Immunophilins
304 abnormal binding (GO:0005488) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
370 increased binding (GO:0005488) major urinary protein (rat) (PR:P02761) 714: Increased, Binding of chemicals to 2u (serum)
133 decreased bicarbonate transport (GO:0015701) hydrogencarbonate (CHEBI:17544) 49: Reduction, Ca and HCO3 transport to shell gland
539 increased beta2-adrenergic receptor activity (GO:0004941) beta-2 adrenergic receptor (PR:000001193) 1039: Increased activity, beta-2 adrenergic receptor