Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 901 to 925 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
549 decreased bile (UBERON:0001970) 1058: Decreased, bile flow
582 decreased carboxylation reaction (MI:1139) prothrombin (PR:000007299) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
583 decreased carboxylation reaction (MI:1139) coagulation factor VII (mouse) (PR:P70375) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
584 decreased carboxylation reaction (MI:1139) coagulation factor IX (mouse) (PR:P16294) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
585 decreased carboxylation reaction (MI:1139) coagulation factor X (mouse) (PR:O88947) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
586 decreased transport (GO:0006810) nutrient (CHEBI:33284) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
589 decreased blood coagulation factors (MESH:D001779) 1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
590 decreased hemostasis (GO:0007599) 1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
592 decreased signaling (GO:0023052) androgen receptor (PR:000004191) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
593 decreased catalytic activity (GO:0003824) Vitamin K Epoxide Reductases (MESH:D064417) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
597 decreased wellness/fitness trait (VT:1000152) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
602 decreased carboxylation reaction (MI:1139) matrix Gla protein (mouse) (PR:P19788) 1169: Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
603 decreased catalytic activity (GO:0003824) iodotyrosine deiodinase 1 (human) (PR:Q6PHW0) 1152: Inhibition, Iodotyrosine deiodinase (IYD)
604 decreased catalytic activity (GO:0003824) type III iodothyronine deiodinase (PR:000006482) 1153: Inhibition, Deiodinase 3
605 decreased signaling (GO:0023052) pendrin (PR:000015039) 1155: Inhibition, Pendrin
606 decreased catalytic activity (GO:0003824) dual oxidase 1 (PR:000006727) 1156: Inhibition, Dual oxidase
616 decreased rhythmic excitation (GO:0043179) vagus nerve (UBERON:0001759) 1220: Trigeminal nerve activation
635 decreased signaling (GO:0023052) sodium channel protein type 1 subunit alpha (PR:000002095) 584: Inhibition, sodium channel
636 decreased transport (GO:0006810) sodium(1+) (CHEBI:29101) 1176: Decreased, sodium conductance 2
637 decreased transport (GO:0006810) gamma-aminobutyric acid (CHEBI:16865) 1179: Decreased, GABA release
648 decreased cell activation (GO:0001775) 1197: Activation, Fibroblasts
649 decreased macrophage activation (GO:0042116) 1198: Activation, Macrophages
664 decreased function (MI:0613) mitochondrion (GO:0005739) 1260: Direct mitochondrial inhibition
676 decreased glutathione synthase activity (GO:0004363) glutathione synthetase (PR:000008293) 1286: Down Regulation, GSS and GSTs gene
677 decreased glutathione transferase activity (GO:0004364) glutathione S-transferase (PR:000029945) 1286: Down Regulation, GSS and GSTs gene