Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 901 to 925 of 1152 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


538	increased	beta-2 adrenergic receptor binding (GO:0031698)	beta-2 adrenergic receptor (PR:000001193)	1038: Activation, beta-2 adrenergic receptor
1072	abnormal	behavior (GO:0007610)		2301: Abnormal, Behavior
1058	occurrence	B cell activation involved in immune response (GO:0002312)	B cell (CL:0000236)	2256: Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation
443	occurrence	autophagic cell death (GO:0048102)	renal tubule (UBERON:0009773)	818: Occurrence, Cytoplasmic vacuolization (Renal tubule)
450	occurrence	autophagic cell death (GO:0048102)		4 Events 833: Occurrence, Cytoplasmic vacuolization (hepatocyte) 835: Occurrence, Ballooning degeneration (hepatocyte) 836: Occurrence, Cytoplasmic vacuolization (Bile duct cell) 837: Occurrence, Cytoplasmic vacuolization (kupffer cell)
349	decreased	attraction-related behavior (NBO:0000280)		674: Reduced, Ability to attract spawning mates
460	increased	atrophy (MESH:D001284)	olfactory epithelium (UBERON:0001997)	868: Increase, Tissue Degeneration, Necrosis & Atrophy
796	decreased	ATP synthesis coupled proton transport (GO:0015986)	mitochondrion (GO:0005739)	None
119	decreased	ATP biosynthetic process (GO:0006754)	ATP (CHEBI:15422)	4 Events 40: Mitochondrial ATP production, decreased 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP 1771: Decrease, Adenosine triphosphate pool 1472: Decrease, ATP production
942	increased	Atherosclerosis (HP:0002621)		1443: Atherosclerosis
80	increased	ataxia (MP:0001393)		3 Events 39: Increased Cholinergic Signaling 602: Increased, Ataxia, paralysis, or hyperactivity 764: N/A, Ataxia, paralysis, or hyperactivity
1073	increased	aryl hydrocarbon receptor binding (GO:0017162)	aryl hydrocarbon receptor (PR:000003858)	18: Activation, AhR
101	increased	aryl hydrocarbon receptor activity (GO:0004874)	aryl hydrocarbon receptor (PR:000003858)	18: Activation, AhR
361	increased	Arrhythmias, Cardiac (MESH:D001145)		699: Increased, cardiac arrthymia
423	decreased	aromatase activity (GO:0070330)	aromatase isoform 1 (PR:000038849)	800: Decreased, Aromatase (Cyp19a1) mRNA
32	decreased	aromatase activity (GO:0070330)	aromatase (PR:000006100)	3 Events 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) 36: Inhibition, Aromatase 800: Decreased, Aromatase (Cyp19a1) mRNA
1083	increased	aromatase activity (GO:0070330)	aromatase (PR:000006100)	2293: Aromatase, induction
327	decreased	aquatic locomotion (NBO:0000371)		2 Events 586: Reduced, swimming speed 1005: Reduced, Swimming performance
314	increased	Appetite (MESH:D001066)		574: Increased, Appetite and hunger
266	increased	apoptotic process (GO:0006915)		3 Events 496: Increased apoptosis, decreased fetal/adult Leydig Cells 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells 1262: Apoptosis
285	increased	apoptotic process (GO:0006915)	Leydig cell (CL:0000178)	648: Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells
820	decreased	apoptotic process (GO:0006915)	ciliated epithelial cell (CL:0000067)	914: Decrease, Apoptosis of ciliated epithelial cells
207	decreased	apoptotic process (GO:0006915)		2 Events 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis 1183: Decreased, Apoptosis (Epithelial Cells)
491	abnormal	antioxidant activity (GO:0016209)	glutathione (CHEBI:16856)	926: Oxidation, Glutathione (To be considered with MIE)
629	increased	antigen processing and presentation (GO:0019882)	hapten (CHEBI:59174)	1236: Generation of novel epitopes , Antigen presentation