Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 926 to 950 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
15 increased muscle contraction (GO:0006936)
16 increased mortality (MESH:D009026)
21 decreased excitatory postsynaptic potential (GO:0060079) 1268: Decrease, Excitatory postsynaptic potential
27 decreased ketosis (MESH:D007662)
28 abnormal abnormal lipid homeostasis (MP:0002118) 862: Not Increased, Circulating Ketone Bodies
31 decreased weight loss (MP:0001263) None
35 decreased fertility (MESH:D005298) 406: decreased, Fertility
36 disrupted ovulation cycle (GO:0042698) None
44 abnormal chemical synaptic transmission (GO:0007268) None
45 increased cochlear degeneration (MP:0000032) 319: Loss, Cochlear function
50 occurrence membrane depolarization (GO:0051899) 616: Occurrence, A paroxysmal depolarizing shift
51 decreased chemical synaptic transmission (GO:0007268) 669: Reduction, Neuronal synaptic inhibition
52 occurrence excitatory postsynaptic potential (GO:0060079) 682: Generation, Amplified excitatory postsynaptic potential (EPSP)
53 occurrence seizures (NBO:0000025) 613: Occurrence, Epileptic seizure
57 increased cell death (GO:0008219)
58 increased neurodegeneration (MP:0002229) 352: N/A, Neurodegeneration
59 decreased learning (GO:0007612) 341: Impairment, Learning and memory
63 decreased synaptic signaling (GO:0099536)
64 decreased memory (GO:0007613) 341: Impairment, Learning and memory
67 decreased cytokine production involved in inflammatory response (GO:0002534) 152: Suppression, Inflammatory cytokines
71 increased Disease Susceptibility (MESH:D004198) 323: Increased, Disease susceptibility
79 increased respiratory distress (MP:0001954) 445: Respiratory distress/arrest
80 increased ataxia (MP:0001393)
81 increased hyperactivity (MP:0001399)
82 increased paralysis (MP:0000753)