Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 76 to 100 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
737 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron (CL:0000540) 1623: Occurrence, Focal Seizure
872 occurrence receptor binding (GO:0005102) angiotensin-converting enzyme 2 (PR:000003622) 1739: Binding to ACE2
877 occurrence endocytosis involved in viral entry into host cell (GO:0075509) cathepsin L1 (human) (PR:P07711) 1738: SARS-CoV-2 cell entry
875 occurrence membrane fusion (GO:0061025) host cell membrane (GO:0033644) None
803 occurrence phosphorylation (GO:0016310) epidermal growth factor receptor (PR:000006933) None
736 occurrence EEG with focal epileptiform discharges (HP:0011185) neuron part (GO:0097458) None
929 occurrence receptor-mediated endocytosis (GO:0006898) clathrin-coated vesicle membrane (GO:0030665) None
912 occurrence abnormal blood coagulation (MP:0002551) blood (UBERON:0000178) 1845: Coagulation
899 occurrence Blood vessel (FMA:63183) None
931 occurrence receptor-mediated endocytosis (GO:0006898) influenzavirus hemagglutinin (PR:000049750) 2159: Influenza A virus (IAV) cell entry
944 occurrence clathrin-dependent endocytosis (GO:0072583) None
934 occurrence toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None
930 occurrence protein localization to endosome (GO:0036010) clathrin-coated vesicle membrane (GO:0030665) 2159: Influenza A virus (IAV) cell entry
880 occurrence cellular response to exogenous dsRNA (GO:0071360) RNA viral genome (GO:0019022) 1901: Interferon-I antiviral response, antagonized by SARS-CoV-2
662 occurrence Translocation, Genetic (MESH:D014178) 1253: MLL chromosomal translocation
948 occurrence protein import into nucleus (GO:0006606) viral RNA-directed RNA polymerase complex (GO:0031381) 2192: Influenza A Virus production increased
956 occurrence viral budding from plasma membrane (GO:0046761) 2193: Influenza A Virus (IAV) budding
955 occurrence modulation by virus of host immune response (GO:0075528) 2180: Immune mechanisms antagonized by viral proteins
947 occurrence membrane fusion (GO:0061025) influenzavirus hemagglutinin (PR:000049750) None
946 occurrence pH reduction (GO:0045851) endosome (GO:0005768) None
945 occurrence vesicle targeting, plasma membrane to endosome (GO:0048201) None
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
105 morphological change abnormal cardiovascular system physiology (MP:0001544) 317: Altered, Cardiovascular development/function
95 morphological change male reproductive organ (UBERON:0003135) 348: Malformation, Male reproductive tract
223 morphological change anatomical structure morphogenesis (GO:0009653) 1001: Increased, Developmental Defects