Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 76 to 100 of 1147 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


57	increased	cell death (GO:0008219)		2 Events 55: Increase, Cell injury/death 768: Increase, Cytotoxicity
860	increased	DNA damage response, detection of DNA damage (GO:0042769)	site of DNA damage (GO:0090734)	2 Events 2006: Secondary genotoxicity 1669: Increased, DNA damage and mutation
619	increased		cough (MESH:D003371)	2 Events 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea 1226: Increased Respiratory irritability and Chronic Cough,
109	decreased	egg quantity (VT:1000294)		2 Events 78: Reduction, Cumulative fecundity and spawning 972: Decreased fertility, Reduced number of oocytes ovulated
510	decreased	luteinizing hormone secretion (GO:0032275)	Luteinizing hormone (CHEBI:81568)	2 Events 970: Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs 1050: Increased, secretion of LH from anterior pituitary
63	decreased	synaptic signaling (GO:0099536)		2 Events 386: Decrease of neuronal network function 618: Decreased, Neuronal network function in adult brain
129	occurrence		cholestasis (MESH:D002779)	2 Events 357: Cholestasis, Pathology 1059: Increased, cholestasis
138	increased		vitellogenins (MESH:D014819)	2 Events 220: Increase, Plasma vitellogenin concentrations 419: Increased, renal vitellogenin deposition
144	decreased	estrogen receptor activity (GO:0030284)	estrogen receptor (PR:000007204)	2 Events 112: Antagonism, Estrogen receptor 1046: Suppression, Estrogen receptor (ER) activity
142	abnormal	larval development (GO:0002164)		2 Events 339: Altered, Larval development 566: impaired, Larval development
174	increased	gene expression (GO:0010467)	acyl-CoA desaturase (PR:000014497)	2 Events 258: Activation, SCD-1 462: Up Regulation, SCD-1
183	decreased	peroxisome proliferator activated receptor signaling pathway (GO:0035357)	peroxisome proliferator-activated receptor gamma (PR:000013058)	2 Events 233: Decreased, PPAR-gamma activation 1028: Activation of specific nuclear receptors, PPAR-gamma activation
227	increased	hepatocyte proliferation (GO:0072574)	hepatocyte (CL:0000182)	2 Events 491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) 716: Increase, cell proliferation (hepatocytes)
151	increased		erythrocyte (CL:0000232)	2 Events 246: Increase, RBC congestion in liver 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
280	decreased	cholesterol biosynthetic process (GO:0006695)	cholesterol (CHEBI:16113)	2 Events 642: Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol 807: Decreased, cholesterol
275	decreased	receptor transactivation (GO:0035624)	COUP transcription factor 2 (PR:000011405)	2 Events 656: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) 541: Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
265	decreased	hormone biosynthetic process (GO:0042446)	testosterone (CHEBI:17347)	2 Events 495: Repressed expression of steroidogenic enzymes 1690: Decrease, circulating testosterone levels
303	increased	colony collapse (MESH:D056631)		2 Events 563: Death/Failure, Colony 1107: Weakened, Colony
325	decreased	sodium channel inhibitor activity (GO:0019871)	sodium channel protein type 1 subunit alpha (PR:000002095)	2 Events 584: Inhibition, sodium channel 598: modulation, sodium channel
94	decreased		testosterone (CHEBI:17347)	2 Events 446: Reduction, fetal/adult testosterone 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
327	decreased	aquatic locomotion (NBO:0000371)		2 Events 586: Reduced, swimming speed 1005: Reduced, Swimming performance
96	decreased	androgen receptor activity (GO:0004882)	androgen receptor (PR:000004191)	2 Events 26: Antagonism, Androgen receptor 1614: Decrease, androgen receptor activation
386	increased	hypertrophy (MESH:D006984)	thyroid follicular cell (CL:0002258)	2 Events 739: Increase, Hypertrophy and proliferation (follicular cell) 1024: Increased, Hypertrophy and proliferation (follicular cell)
397	increased	chloride channel activity (GO:0005254)	glutamate-gated chloride channel (fruit fly) (PR:Q94900)	2 Events 760: Activation, Glutamate-gated chloride channel 1018: Activation, Glutamate-gated chloride channels
385	increased	cell proliferation (GO:0008283)	thyroid follicular cell (CL:0002258)	2 Events 739: Increase, Hypertrophy and proliferation (follicular cell) 1024: Increased, Hypertrophy and proliferation (follicular cell)