Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 76 to 100 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
91 decreased gene expression (GO:0010467) translocator protein (PR:000016757) 289: Decrease, Translocator protein (TSPO)
614 increased signaling (GO:0023052) transient receptor potential cation channel TRPV1 (PR:000001065)
472 increased phosphorylation (GO:0016310) transcription factor Sp1 (PR:000000133) 924: Activation, Sp1
66 decreased I-kappaB kinase/NF-kappaB signaling (GO:0007249) transcription factor NF-kappa-B subunit (PR:000001753) 202: Inhibition, Nuclear factor kappa B (NF-kB)
870 increased toll-like receptor 4 signaling pathway (GO:0034142) Toll-like receptor 4 (PR:000001155) 1495: Substance interaction with the lung resident cell membrane components
869 increased toll-like receptor signaling pathway (GO:0002224) Toll-like receptor (PR:000001096) 1495: Substance interaction with the lung resident cell membrane components
693 increased cell activation involved in immune response (GO:0002263) tissue-resident macrophage (CL:0000864) None
1067 increased hormone activity (GO:0005179) tissue (UBERON:0000479) None
504 increased thyroxine (CHEBI:30660)
505 increased transport (GO:0006810) thyroxine (CHEBI:30660) 960: Increased, Uptake of thyroxine into tissue
506 increased metabolic process (GO:0008152) thyroxine (CHEBI:30660) 961: Increased, Clearance of thyroxine from serum
41 decreased thyroxine (CHEBI:30660)
706 decreased regulation of hormone levels (GO:0010817) thyroxine (CHEBI:30660) 280: Thyroxine (T4) in neuronal tissue, Decreased
530 increased hormone catabolic process (GO:0042447) thyroxine (CHEBI:30660) 1021: Increased, T4/T3 catabolism
710 decreased abnormal circulating thyroxine level (MP:0005475) thyroxine (CHEBI:30660) 281: Thyroxine (T4) in serum, Decreased
388 increased Thyroid stimulating hormone (CHEBI:81567)
417 increased increased thyroid-stimulating hormone level (MP:0005135) Thyroid stimulating hormone (CHEBI:81567) 753: Increase, Thyroid-stimulating hormone (TSH)
213 decreased iodide peroxidase activity (GO:0004447) thyroid peroxidase (PR:000016584) 279: Thyroperoxidase, Inhibition
214 decreased thyroid hormone generation (GO:0006590) thyroid hormone (CHEBI:60311) 277: Thyroid hormone synthesis, Decreased
608 increased transport (GO:0006810) thyroid hormone (CHEBI:60311) 1158: Increased, Hepatic thyroid hormone uptake/transport
386 increased hypertrophy (MESH:D006984) thyroid follicular cell (CL:0002258)
385 increased cell proliferation (GO:0008283) thyroid follicular cell (CL:0002258)
387 increased hyperplasia (MESH:D006965) thyroid follicular cell (CL:0002258)
157 increased metabolic process (GO:0008152) thiamethoxam (CHEBI:39185) 77: Production, Critical Metabolites (CGA 330050 and CGA 265307)
193 increased transforming growth factor beta1 production (GO:0032905) TGF-beta 1 (PR:000000182) 276: Up Regulation, TGFbeta1 expression