Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 76 to 100 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
746 decreased T cell activation involved in immune response (GO:0002286) 1719: Impairment of T-cell dependent antibody response
1041 increased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) None
903 decreased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 1702: Suppression of T cell activation
203 increased T cell activation (GO:0042110) T cell (CL:0000084) 272: Activation/Proliferation, T-cells
822 increased synaptic transmission, glutamatergic (GO:0035249) glutamate(1-) (CHEBI:14321) None
821 increased synaptic transmission, glutamatergic (GO:0035249) None
823 increased synaptic transmission, glutamatergic (GO:0035249) L-glutamate(1-) (CHEBI:29985) 1350: Increased, glutamate
395 increased synaptic transmission, dopaminergic (GO:0001963) 746: Increase, Dopaminergic activity
568 increased synaptic transmission, dopaminergic (GO:0001963) dopaminergic neuron (CL:0000700) 1083: Decreased, Dopaminergic activity
63 decreased synaptic signaling (GO:0099536)
62 decreased synapse assembly (GO:0007416) synapse (GO:0045202) 385: Decrease of synaptogenesis
524 decreased swim bladder inflation (GO:0048798) anterior chamber swim bladder (UBERON:2001277) 1007: Reduced, Anterior swim bladder inflation
522 decreased swim bladder inflation (GO:0048798) posterior chamber swim bladder (UBERON:2001278) 1004: Reduced, Posterior swim bladder inflation
523 decreased survival (MESH:D013534) None
70 increased suppression of host defenses (GO:0044414) immune system (UBERON:0002405) 403: Suppression, Immune system
953 occurrence suppression by virus of host cytokine production (GO:0046775) 2180: Immune mechanisms antagonized by viral proteins
1012 decreased sulfotransferase activity (GO:0008146) estrogen sulfotransferase (PR:000032783) 2155: Inhibition of Sulfotransferase E1 (SULT1E1)
918 decreased succinate metabolic process (GO:0006105) succinate dehydrogenase complex (GO:0045281) 2118: Succinate dehydrogenase, inhibited
916 decreased succinate dehydrogenase activity (GO:0000104) 2118: Succinate dehydrogenase, inhibited
313 increased Stress, Physiological (MESH:D013312)
1019 increased Stress, Physiological (MESH:D013312) heart (UBERON:0000948) 2239: Increased, Cardiac stress
990 occurrence Stress, Physiological (MESH:D013312) heart (UBERON:0000948) None
409 increased stomach epithelial hyperplasia (MP:0005493) epithelial cell (CL:0000066) 782: Increase, Hyperplasia (forestomach epithelial cells)
355 decreased steroid hormone receptor activity (GO:0003707) steroid hormone (CHEBI:26764) 692: Reduced, Maturation inducing steroid receptor signalling, oocyte
283 decreased steroid biosynthetic process (GO:0006694) 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell