Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 976 to 1000 of 1152 KECs

ID	Action	Process	Associated Key Events (KEs)


200	increased	cytokine production involved in inflammatory response (GO:0002534)	826: Activation, Keratinocytes
201	increased	cell activation (GO:0001775)	3 Events 398: Activation, Dendritic Cells 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 981: Reduction, NFAT/AP-1 complex formation
202	increased	MHC protein complex assembly (GO:0002396)	398: Activation, Dendritic Cells
206	abnormal	cellular homeostasis (GO:0019725)	853: Changes/Inhibition, Cellular Homeostasis and Apoptosis
207	decreased	apoptotic process (GO:0006915)	2 Events 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis 1183: Decreased, Apoptosis (Epithelial Cells)
215	decreased	learning or memory (GO:0007611)	402: Cognitive function, decreased
216	decreased	cognition (GO:0050890)	402: Cognitive function, decreased
219	decreased	angiogenesis (GO:0001525)	28: Reduction, Angiogenesis
220	abnormal	endothelium development (GO:0003158)	110: Impairment, Endothelial network
223	morphological change	anatomical structure morphogenesis (GO:0009653)	1001: Increased, Developmental Defects
225	increased	metabolic process (GO:0008152)	409: Metabolism of AFB1, Production of Reactive Electrophiles
231	abnormal	sex ratio (MESH:D012744)	417: skewed, sex ratio
233	increased	hemorrhage (MP:0001914)	2 Events 421: Increased, glomerular rupture and renal hemorrhaging 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
234	increased	Nephropathy (HP:0000112)	422: Increased, nephropathy
237	abnormal	abnormal neuron morphology (MP:0002882)	851: Decrease of GABAergic interneurons
488	increased	increased systemic vascular resistance (MP:0004878)	951: KE8 : Increase, Vascular Resistance
489	increased	hypertension (MP:0000231)	952: Hypertension
496	increased	pericardial edema (MP:0001787)	358: Increase, Pericardial edema
497	increased	embryonic lethality (MP:0008762)	947: Increase, Early Life Stage Mortality
511	abnormal	ovulation cycle (GO:0042698)	971: Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
514	increased	Immunosuppression (MESH:D007165)	None
523	decreased	survival (MESH:D013534)	None
525	decreased	sensory perception of sound (GO:0007605)	1008: Reduced, Hearing
527	increased	inhibitory postsynaptic potential (GO:0060080)	1012: Increased, Inhibitory postsynaptic potential
531	increased	fat cell differentiation (GO:0045444)	1029: Increased, adipogenesis