Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1001 to 1025 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
892 decreased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) None
893 decreased abnormal palatal shelf fusion at midline (MP:0009887) secondary palate (UBERON:0001716) None
896 decreased second-messenger-mediated signaling (GO:0019932) None
897 decreased protein localization to cilium (GO:0061512) smoothened (PR:000015288) 2044: Decrease, Smoothend relocation and activation
898 decreased decreased triiodothyronine level (MP:0005473) 3,3',5'-triiodothyronine (CHEBI:28774) 1003: Decreased, Triiodothyronine (T3)
903 decreased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 1702: Suppression of T cell activation
906 decreased sonic hedgehog protein (PR:000014841) None
907 decreased second-messenger-mediated signaling (GO:0019932) sonic hedgehog protein (PR:000014841) 2043: Decrease, Sonic Hedgehog second messenger production
911 decreased abnormal glutathione level (MP:0012603) glutathione (CHEBI:16856) 130: Depletion, GSH
913 decreased fibrinolysis (GO:0042730) Fibrin (CHEBI:5054) None
914 decreased fibrinolysis (GO:0042730) 1846: Thrombosis and Disseminated Intravascular Coagulation
916 decreased succinate dehydrogenase activity (GO:0000104) 2118: Succinate dehydrogenase, inhibited
917 decreased FAD metabolic process (GO:0046443) succinate dehydrogenase complex (GO:0045281) 2118: Succinate dehydrogenase, inhibited
918 decreased succinate metabolic process (GO:0006105) succinate dehydrogenase complex (GO:0045281) 2118: Succinate dehydrogenase, inhibited
923 decreased signaling (GO:0023052) neurotransmitter (CHEBI:25512) 2151: Disruption, neurotransmitter release
936 decreased toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None
937 decreased toll-like receptor 7 signaling pathway (GO:0034154) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
938 decreased toll-like receptor 3 signaling pathway (GO:0034138) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
939 decreased sexual reproduction (GO:0019953) 2147: Decreased, Viable Offspring
940 decreased decreased body weight (MP:0001262) 864: Decreased, Body Weight
964 decreased viable offspring quantity (VT:1000181) 2147: Decreased, Viable Offspring
965 decreased hormone biosynthetic process (GO:0042446) None
967 decreased hormone biosynthetic process (GO:0042446) 17beta-Hydroxy-2-oxa-5alpha-androstan-3-one (CHEBI:79436) 1613: Decrease, dihydrotestosterone (DHT) levels
978 decreased interleukin-1 receptor activity (GO:0004908) interleukin-1 receptor type I (PR:000001363) 1700: Impaired IL-1R1 signaling in T cell
982 decreased impaired synaptic plasticity (MP:0001900) actin cytoskeleton of dendritic spine (GO:0098938) None