Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1001 to 1025 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1150 increased Abnormality of cellular immune system (HP:0010987) B7-related protein (PR:000001290) 2323: Over-expression of PD-L1 in cancer cells
31 decreased weight loss (MP:0001263) None
36 disrupted ovulation cycle (GO:0042698) None
43 morphological change hippocampal formation (UBERON:0002421) None
44 abnormal chemical synaptic transmission (GO:0007268) None
61 decreased glutamate secretion, neurotransmission (GO:0061535) glutamate(1-) (CHEBI:14321) None
74 functional change DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) None
86 decreased glutathione (CHEBI:16856) None
87 occurrence oxidative stress (MP:0003674) None
102 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor (PR:000003858) None
103 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) None
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
177 functional change mitochondrion disassembly (GO:0061726) mitochondrion (GO:0005739) None
187 increased fatty liver (MESH:D005234) None
365 increased epithelial cell proliferation (GO:0050673) nephron tubule epithelial cell (CL:1000494) None
418 decreased catalytic activity (GO:0003824) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (rat) (PR:P31214) None
429 decreased cholesterol (CHEBI:16113) None
474 decreased epithelial cell apoptotic process (GO:1904019) None
480 increased secretion (GO:0046903) mucin-5AC (PR:000031343) None
482 occurrence mucus secretion (GO:0070254) None
508 decreased estrogen (CHEBI:50114) None
509 decreased neurotransmitter secretion (GO:0007269) metastasis-suppressor KiSS-1 (rat) (PR:Q7TSB7) None
514 increased Immunosuppression (MESH:D007165) None
523 decreased survival (MESH:D013534) None
556 morphological change Metaplasia (MESH:D008679) None