Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1001 to 1025 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
559 disrupted abnormal ovulation (MP:0001928) 1074: interruption, Ovulation
560 delayed estrus (GO:0060209) None
563 increased mammary gland hyperplasia (MP:0000630) 1078: Hyperplasia, Mammary gland
564 increased abnormal tumor latency (MP:0010307) 1080: Increased, latency period
574 increased metamorphosis (GO:0007552) 1101: Altered, Amphibian metamorphosis
578 abnormal role (MESH:D012380) 1108: Abnormal, Role change within caste
580 abnormal hemostasis (GO:0007599) 1122: Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis
581 abnormal wound healing (GO:0042060) 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
587 abnormal cellular detoxification (GO:1990748) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
588 occurrence anemia (MP:0001577) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
590 decreased hemostasis (GO:0007599) 1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
594 increased acidosis (MP:0003031) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
595 increased hypovolemia (MP:0010128) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
597 decreased wellness/fitness trait (VT:1000152) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
598 increased oxidative phosphorylation uncoupler activity (GO:0017077) 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
599 increased osteoporosis (MP:0000066) 1151: Osteoporosis and vascular calcification, Bone deterioration
611 increased reproductive process (GO:0022414) 1163: Increased, Reproductive Success
622 increased dermatitis (MP:0001194)
624 increased abnormal acute inflammation (MP:0002498) 1225: Immune system inflammation
630 increased immune response (GO:0006955) 1237: Sensitization, Immune system
641 increased endothelial cell proliferation (GO:0001935) 1189: Increased, Proliferation (Endothelial cells)
642 increased endothelial cell migration (GO:0043542) 1190: Increased, Migration (Endothelial Cells)
643 increased signaling (GO:0023052) 1191: Increased, Non-genomic signaling
648 decreased cell activation (GO:0001775) 1197: Activation, Fibroblasts
649 decreased macrophage activation (GO:0042116) 1198: Activation, Macrophages