Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 1001 to 1025 of 1150 KECs

ID	Action	Object	Associated Key Events (KEs)


41	decreased	thyroxine (CHEBI:30660)	3 Events 771: Decrease, Serum thyroid hormone (T4/T3) 1022: Decreased, serum T4/T3 1093: Decreased, Thyroxine (T4) in tissues
43	morphological change	hippocampal formation (UBERON:0002421)	None
68	decreased	lymphocyte (CL:0000542)	168: Decreased, Lymphocytes
76	increased	acetylcholine (CHEBI:15355)	10: Acetylcholine accumulation in synapses
77	increased	atrioventricular block (MESH:D054537)	444: Increased, Atrioventricular block and bradycardia
78	increased	decreased heart rate (MESH:D001919)	444: Increased, Atrioventricular block and bradycardia
86	decreased	glutathione (CHEBI:16856)	None
94	decreased	testosterone (CHEBI:17347)	2 Events 446: Reduction, fetal/adult testosterone 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
95	morphological change	male reproductive organ (UBERON:0003135)	348: Malformation, Male reproductive tract
100	decreased	fertility (MESH:D005298)	6 Events 337: N/A, Impairment of reproductive capacity 505: Decreased sperm quantity / quality in the adult, Decreased fertility 520: Decreased sperm quantity or quality in the adult, Decreased fertility 527: Decreased, Decreased fecundity 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis 330: Decrease, Fertility
110	decreased	vitellogenins (MESH:D014819)	221: Reduction, Plasma vitellogenin concentrations
114	decreased	Luteinizing hormone (CHEBI:81568)	2 Events 129: Reduction, Gonadotropins, circulating concentrations 690: Reduced, Luteinizing hormone (LH), plasma
115	decreased	Follicle stimulating hormone (CHEBI:81569)	129: Reduction, Gonadotropins, circulating concentrations
117	increased	calcium ion (CHEBI:39124)	50: Increase, Ca++ (intracellular)
118	disrupted	mitochondrial respiratory chain (GO:0005746)	178: Mitochondrial electron transport chain, disrupted
121	decreased	nitric oxide (CHEBI:16480)	193: Decreased, Nitric Oxide
126	increased	bile (UBERON:0001970)	214: Bile accumulation, Pathological condition
129	occurrence	cholestasis (MESH:D002779)	2 Events 357: Cholestasis, Pathology 1059: Increased, cholestasis
132	decreased	prostaglandin E2 (CHEBI:15551)	2 Events 243: Reduction, Prostaglandin E2 concentration 687: Reduced, Prostaglandin E2 concentration, hypothalamus
134	decreased	eggshell (UBERON:0005079)	106: Reduction, Eggshell thickness
135	functional change	eggshell (UBERON:0005079)	119: N/A, Gap
138	increased	vitellogenins (MESH:D014819)	2 Events 220: Increase, Plasma vitellogenin concentrations 419: Increased, renal vitellogenin deposition
147	increased	hemolysis (MESH:D006461)	250: Damaging, Red blood cells; hemolysis
151	increased	erythrocyte (CL:0000232)	2 Events 246: Increase, RBC congestion in liver 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
153	increased	hemosiderosis (MESH:D006486)	161: Increase, Liver and splenic hemosiderosis