Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1026 to 1050 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
163 increased hepatocellular carcinoma (MESH:D006528)
176 increased triglyceride (CHEBI:17855) 291: Accumulation, Triglyceride
178 occurrence fatty liver (MESH:D005234) 345: N/A, Liver Steatosis
179 increased membrane (GO:0016020) 46: Accumulation, Biological membranes
180 abnormal plasma membrane (GO:0005886) 169: Disruption, Membrane integrity
184 increased fatty acid (CHEBI:35366) 327: Accumulation, Fatty acid
187 increased fatty liver (MESH:D005234) None
208 occurrence Liver Diseases (MESH:D008107) 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects
212 increased Bile Duct Neoplasms (MESH:D001650) 856: Formation, Hepatocellular and Bile duct tumors
222 abnormal capillary plexus (UBERON:0035753) 298: Insufficiency, Vascular
232 functional change glomerular basement membrane (UBERON:0005777) 421: Increased, glomerular rupture and renal hemorrhaging
774 increased deoxyribonucleic acid (CHEBI:16991) 1879: Bulky DNA adducts, increase
795 decreased mitochondrion (GO:0005739) None
800 decreased epithelial lining fluid (UBERON:0035963) 1907: Airway Surface Liquid Height, Decreased
807 decreased motile cilium (GO:0031514) 1912: Motile Cilia Number/Length, Decreased
808 decreased forkhead box protein J1 (PR:000007628) 1911: FOXJ1 Protein, Decreased
809 decreased cftr isoform 1 (PR:000001045) None
814 decreased angiotensin-converting enzyme 2 (PR:000003622) None
818 increased angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
839 disrupted barrier epithelial cell (CL:0000073) 1931: Intestinal barrier, disruption
844 increased StAR-related lipid transfer protein 4 (human) (PR:Q96DR4) None
848 increased transmembrane protease serine 2 (human) (PR:O15393) None
852 increased Cytokine (FMA:84050) None
856 increased Interleukin (FMA:86578) 1496: Increased, secretion of proinflammatory mediators
882 decreased smoothened (PR:000015288) None