Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1051 to 1075 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
755 increased viral RNA genome replication (GO:0039694) None
760 increased viral RNA genome packaging (GO:0019074) None
767 increased endocytosis involved in viral entry into host cell (GO:0075509) None
768 increased protease binding (GO:0002020) None
769 increased neuropilin binding (GO:0038191) None
770 disrupted mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (PR:000003622) None
772 occurrence epithelial to mesenchymal transition (GO:0001837) cellular_component (GO:0005575) None
775 decreased protein secretion (GO:0009306) None
786 decreased pattern recognition receptor signaling pathway (GO:0002221) RNA viral genome (GO:0019022) None
787 decreased type I interferon signaling pathway (GO:0060337) signalling molecule (CHEBI:62488) None
788 decreased cellular response to type I interferon (GO:0071357) type I interferon receptor complex (GO:0038197) None
789 decreased transcription, DNA-templated (GO:0006351) None
790 decreased translation (GO:0006412) None
792 decreased epithelial cilium movement (GO:0003351) None
793 decreased regulation of cilium movement (GO:0003352) None
795 decreased mitochondrion (GO:0005739) None
796 decreased ATP synthesis coupled proton transport (GO:0015986) mitochondrion (GO:0005739) None
801 decreased Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) None
803 occurrence phosphorylation (GO:0016310) epidermal growth factor receptor (PR:000006933) None
809 decreased cftr isoform 1 (PR:000001045) None
812 increased mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (human) (PR:Q9BYF1) None
813 increased regulation of peptidase activity (GO:0052547) angiotensin-converting enzyme (human) (PR:P12821) None
814 decreased angiotensin-converting enzyme 2 (PR:000003622) None
821 increased synaptic transmission, glutamatergic (GO:0035249) None
822 increased synaptic transmission, glutamatergic (GO:0035249) glutamate(1-) (CHEBI:14321) None