Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1101 to 1125 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
999 abnormal cell differentiation (GO:0030154) 2245: Altered Cell Differentiation Signaling
1000 abnormal DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) 155: Inadequate DNA repair
1069 abnormal cell redox homeostasis (GO:0045454) 2299: Altered, Redox Homeostasis
1072 abnormal behavior (GO:0007610) 2301: Abnormal, Behavior
1079 abnormal embryonic organ development (GO:0048568) penis (UBERON:0000989) 2082: Hypospadias, increased
1106 abnormal cell differentiation (GO:0030154) cell (GO:0005623) 1560: Cell differentiation, altered
7 abnormal Proteostasis deficiencies (MESH:D057165) protein (CHEBI:36080) 889: Proteostasis, impaired
28 abnormal abnormal lipid homeostasis (MP:0002118) 862: Not Increased, Circulating Ketone Bodies
29 abnormal ketone body (CHEBI:73693) 862: Not Increased, Circulating Ketone Bodies
42 abnormal regulation of gene expression (GO:0010468) hippocampal formation (UBERON:0002421) 756: Hippocampal gene expression, Altered
44 abnormal chemical synaptic transmission (GO:0007268) None
60 abnormal dendrite morphogenesis (GO:0048813) dendrite (GO:0030425) 382: Aberrant, Dendritic morphology
97 abnormal Wnt signaling pathway (GO:0016055) Wnt signalosome (GO:1990909) 310: Alteration, Wnt pathway
136 abnormal multi-organism reproductive process (GO:0044703) 253: N/A, Reproductive failure
141 abnormal reproductive behavior (GO:0019098) 363: Altered, Reproductive behaviour
142 abnormal larval development (GO:0002164)
143 abnormal developmental process (GO:0032502) reproductive organ (UBERON:0003133) 364: Impaired development of, Reproductive organs
146 abnormal gene expression (GO:0010467) hemoglobin subunit alpha (human) (PR:P69905) 21: Altered regulation, Alpha hemoglobin
180 abnormal plasma membrane (GO:0005886) 169: Disruption, Membrane integrity
206 abnormal cellular homeostasis (GO:0019725) 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis
209 abnormal cell proliferation (GO:0008283) Liver cell (FMA:63179) 854: Alterations, Cellular proliferation / hyperplasia
220 abnormal endothelium development (GO:0003158) 110: Impairment, Endothelial network
222 abnormal capillary plexus (UBERON:0035753) 298: Insufficiency, Vascular
224 abnormal DNA alkylation (GO:0006305) Nuclear deoxyribonucleic acid (FMA:67194) 373: Formation, Pro-mutagenic DNA Adducts
231 abnormal sex ratio (MESH:D012744) 417: skewed, sex ratio