Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1101 to 1125 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1011 increased chromosome (GO:0005694) None
1020 decreased neuropathy target esterase (PR:000012946) 2262: Neuropathy target esterase, inhibited
1021 increased lysophosphatidylcholine (CHEBI:60479) 2263: Lysolecithin, increased
1032 increased aromatase (PR:000006100) None
1035 increased alpha-beta T cell receptor complex (GO:0042105) None
1045 decreased insulin-induced gene 1 protein (PR:000009056) None
1084 increased apoptosis regulator BAX (PR:000002193) 2124: increased, Bax expression
1103 increased homeobox protein SIX1 (PR:000014896) None
1130 decreased fibroblast growth factor 10 (PR:000007480) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1131 decreased fibroblast growth factor 2 (PR:000007489) None
263 decreased prostaglandin (CHEBI:26333) 685: Reduced, Prostaglandins, ovary
268 morphological change sperm (CL:0000019) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
271 increased corticosterone (CHEBI:16827) 653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone
277 decreased sperm (CL:0000019)
278 increased estrogen receptor (PR:000007204) 658: Decreased testosterone by the fetal Leydig cells, Increased estradiol
279 abnormal fetal proteins (MESH:D005326) 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
297 abnormal fertilization envelope (GO:0060387) 534: Altered, Formation of cortical envelope
311 decreased population of organisms (PCO:0000001) 572: Decrease, Number of worker bees
329 increased Amputation, Congenital (MESH:C565682) 591: Increased, amputations
345 increased anesthesia (MESH:D000758) 634: N/A, sedation
346 decreased prostaglandin F2alpha (CHEBI:15553)
348 abnormal fertility (MESH:D005298) 673: Reduced, Spawning behavior
352 increased 3',5'-cyclic AMP(1-) (CHEBI:58165) 693: Increased, cyclic adenosine monophosphate
353 decreased Gonadotropin Releasing Hormone (MESH:D007987) 689: Reduced, Gonadotropin releasing hormone, hypothalamus
354 decreased steroid hormone (CHEBI:26764) 691: Reduced, Maturation inducing steroid, plasma